Reaction Details |
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Target | Acid ceramidase |
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Ligand | BDBM50431253 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2057396 (CHEMBL4712397) |
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IC50 | 16±n/a nM |
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Citation | Caputo, S; Di Martino, S; Cilibrasi, V; Tardia, P; Mazzonna, M; Russo, D; Penna, I; Summa, M; Bertozzi, SM; Realini, N; Margaroli, N; Migliore, M; Ottonello, G; Liu, M; Lansbury, P; Armirotti, A; Bertorelli, R; Ray, SS; Skerlj, R; Scarpelli, R Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors. J Med Chem63:15821-15851 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acid ceramidase |
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Name: | Acid ceramidase |
Synonyms: | AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase |
Type: | Enzyme |
Mol. Mass.: | 44450.22 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q6P7S1 |
Residue: | 394 |
Sequence: | MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKR
WHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIAD
VTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEE
LKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMF
GKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKES
LDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTK
PVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
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BDBM50431253 |
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n/a |
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Name | BDBM50431253 |
Synonyms: | CHEMBL2333055 |
Type | Small organic molecule |
Emp. Form. | C16H24FN3O5 |
Mol. Mass. | 357.3773 |
SMILES | CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O |
Structure |
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