| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sorbitol dehydrogenase |
|---|
| Ligand | BDBM50118706 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_223917 (CHEMBL846063) |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Mylari, BL; Oates, PJ; Zembrowski, WJ; Beebe, DA; Conn, EL; Coutcher, JB; O'Gorman, MT; Linhares, MC; Withbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem45:4398-401 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sorbitol dehydrogenase |
|---|
| Name: | Sorbitol dehydrogenase |
|---|
| Synonyms: | DHSO_RAT | Sdh1 | Sord |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38239.67 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_223914 |
|---|
| Residue: | 357 |
|---|
| Sequence: | MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDF
VVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFC
ATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCG
AGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL
GSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRY
CNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
|
|
|
|---|
| BDBM50118706 |
|---|
| n/a |
|---|
| Name | BDBM50118706 |
|---|
| Synonyms: | (S)-1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | 1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | CHEMBL136900 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H32N8O |
|---|
| Mol. Mass. | 412.5318 |
|---|
| SMILES | C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)N1CCN(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
