Reaction Details |
| Report a problem with these data |
Target | C-C chemokine receptor type 2 |
---|
Ligand | BDBM50557877 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2060395 (CHEMBL4715396) |
---|
IC50 | 0.600000±n/a nM |
---|
Citation | Yang, MG; Xiao, Z; Zhao, R; Tebben, AJ; Wang, B; Cherney, RJ; Batt, DG; Brown, GD; Cvijic, ME; Duncia, JV; Gallela, MA; Gardner, DS; Khandelwal, P; Malley, MF; Pang, J; Rose, AV; Santella, JB; Sarjeant, AA; Xu, S; Mathur, A; Mandlekar, S; Vuppugalla, R; Zhao, Q; Carter, PH Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2. ACS Med Chem Lett12:969-975 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
C-C chemokine receptor type 2 |
---|
Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
|
|
|
BDBM50557877 |
---|
n/a |
---|
Name | BDBM50557877 |
Synonyms: | CHEMBL4790208 |
Type | Small organic molecule |
Emp. Form. | C27H41N7O2 |
Mol. Mass. | 495.6601 |
SMILES | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(nc23)C(C)(C)C)C1=O)NC(C)(C)C |r| |
Structure |
|