Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTranslocator protein
LigandBDBM50120352
Substrate/Competitorn/a
Meas. Tech.ChEBML_37065
Ki 208±n/a nM
Citation Pacofsky, GJStafford, JACox, RFCowan, JRDorsey, GFGonzales, SSKaldor, IKoszalka, GWLovell, GGMcIntyre, MSTidwell, JHTodd, DWhitesell, GWiard, RPFeldman, PL Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists. Bioorg Med Chem Lett12:3219-22 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50120352
n/a
NameBDBM50120352
Synonyms:3-{(S)-7-Chloro-5-(2-fluoro-phenyl)-2-[2-(1H-imidazol-4-yl)-ethylamino]-3H-benzo[e][1,4]diazepin-3-yl}-propionic acid methyl ester | CHEMBL326440
TypeSmall organic molecule
Emp. Form.C24H23ClFN5O2
Mol. Mass.467.923
SMILESCOC(=O)CC[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2N=C1NCCc1cnc[nH]1 |c:25,t:7|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: