| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
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| Ligand | BDBM50560791 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2073406 (CHEMBL4728940) |
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| IC50 | 14±n/a nM |
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| Citation |  Czako, B; Marszalek, JR; Burke, JP; Mandal, P; Leonard, PG; Cross, JB; Mseeh, F; Jiang, Y; Chang, EQ; Suzuki, E; Kovacs, JJ; Feng, N; Gera, S; Harris, AL; Liu, Z; Mullinax, RA; Pang, J; Parker, CA; Spencer, ND; Yu, SS; Wu, Q; Tremblay, MR; Mikule, K; Wilcoxen, K; Heffernan, TP; Draetta, GF; Jones, P Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R. J Med Chem63:9888-9911 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage colony-stimulating factor 1 receptor |
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| Name: | Macrophage colony-stimulating factor 1 receptor |
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| Synonyms: | CSF1R_MOUSE | Csf1r | Csfmr | Fms | Macrophage colony-stimulating factor 1 receptor | Macrophage colony-stimulating factor 1 receptor (c-Fms) | Proto-oncogene c-Fms |
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| Type: | Protein |
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| Mol. Mass.: | 109173.45 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P09581 |
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| Residue: | 977 |
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| Sequence: | MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTL
DPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEG
QEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTM
VNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRG
DTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRY
TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVS
GYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMT
YFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQ
KPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDT
YVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCE
PGDIAQPLLQPNNYQFC
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| BDBM50560791 |
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| n/a |
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| Name | BDBM50560791 |
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| Synonyms: | CHEMBL4740157 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26ClN7O3S |
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| Mol. Mass. | 516.016 |
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| SMILES | COc1cc(OCc2ccnc(Nc3cnn(C)c3)n2)c(Cl)c2sc(N[C@H]3CCCC[C@@H]3O)nc12 |r| |
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| Structure | 
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