Reaction Details |
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Target | Methionine--tRNA ligase |
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Ligand | BDBM50112576 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105150 (CHEMBL716780) |
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IC50 | 16±n/a nM |
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Citation | Jarvest, RL; Berge, JM; Brown, MJ; Brown, P; Elder, JS; Forrest, AK; Houge-Frydrych, CS; O'Hanlon, PJ; McNair, DJ; Rittenhouse, S; Sheppard, RJ Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorg Med Chem Lett13:665-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase |
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Name: | Methionine--tRNA ligase |
Synonyms: | Methionyl-tRNA synthetase | SYM_ECOLI | metG |
Type: | PROTEIN |
Mol. Mass.: | 76245.79 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_400681 |
Residue: | 677 |
Sequence: | MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIM
LKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFI
KNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSG
ATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFG
FEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVY
FHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYY
TAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYK
TFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSM
GINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQV
EALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLR
LTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKD
IFLLSPDAGAKPGHQVK
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BDBM50112576 |
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n/a |
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Name | BDBM50112576 |
Synonyms: | 2-(3-(3,4-dichlorobenzylamino)propylamino)quinolin-4(1H)-one | 2-[3-(3,4-Dichloro-benzylamino)-propylamino]-1H-quinolin-4-one | CHEMBL60402 |
Type | Small organic molecule |
Emp. Form. | C19H19Cl2N3O |
Mol. Mass. | 376.28 |
SMILES | Oc1cc(NCCCNCc2ccc(Cl)c(Cl)c2)nc2ccccc12 |
Structure |
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