| Reaction Details |
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 | Report a problem with these data |
| Target | Ecdysone receptor |
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| Ligand | BDBM50128466 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65453 |
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| EC50 | 3000±n/a nM |
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| Citation |  Smith, HC; Cavanaugh, CK; Friz, JL; Thompson, CS; Saggers, JA; Michelotti, EL; Garcia, J; Tice, CM Synthesis and SAR of cis-1-benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems. Bioorg Med Chem Lett13:1943-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Ecdysone receptor |
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| Name: | Ecdysone receptor |
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| Synonyms: | 20-hydroxy-ecdysone receptor | 20E receptor | AaEcR | ECR_AEDAE | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83656.95 |
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| Organism: | Aedes aegypti |
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| Description: | ChEMBL_65453 |
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| Residue: | 776 |
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| Sequence: | MYRLNIVSTNPSGSVQQQQQAQGQQVISSVVRPQQQQPPPQLALVQTGGSGGTTTTIIGL
TSLNALNATTITGLVAGAAGSSTSAIAAAGASNSGSGPSTATTKHILKAATTNNNISIVK
IVDDIMLKAVKVEPLPMDTGGGGGGVSMIPSSATTSGGVTVTAIPASVAPMPPVAAGTNV
SSNGSVTVYASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQSTTYTTTMSNGYSSP
MSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPTPRQQEELCLVCGDRESG
YHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPEC
VVPENQCAIKRKEKKAQKEKDKVQTNATVSTTNSTYRSEILPILMKCDPPPHQAIPLLPE
KLLQENRLRNIPLLTANQMAVIYKLIWYQDGYEQPSEEDLKRIMIGSPNEEEDQHDVHFR
HITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDAATDSILF
ANNRSYTRDSYRMAGMADTIEDLLHFCRQMFSLTVDNVEYALLTAIVIFSDRPGLEQAEL
VEHIQSYYIDTLRIYILNRHAGDPKCSVIFAKLLSILTELRTLGNQNSEMCFSLKLKNRK
LPRFLEEIWDVQDIPPSMQAQMHSHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGP
HPHPHGQQLTPNQQQHQQQHSQLQQVHANGSGSGGGSNNNSSSGGVVPGLGMLDQV
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| BDBM50128466 |
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| n/a |
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| Name | BDBM50128466 |
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| Synonyms: | CHEMBL291513 | [(2R,4S)-6-Fluoro-4-(4-fluoro-phenylamino)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2-fluoro-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F3N2O |
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| Mol. Mass. | 396.405 |
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| SMILES | C[C@@H]1C[C@H](Nc2ccc(F)cc2)c2cc(F)ccc2N1C(=O)c1ccccc1F |
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| Structure | 
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