Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50132560 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_66292 |
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IC50 | 26±n/a nM |
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Citation | Yang, W; Keenan, TP; Rozamus, LW; Wang, X; Rivera, VM; Rollins, CT; Clackson, T; Holt, DA Regulation of gene expression by synthetic dimerizers with novel specificity. Bioorg Med Chem Lett13:3181-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50132560 |
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n/a |
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Name | BDBM50132560 |
Synonyms: | (S)-1-((S)-2-Benzo[1,3]dioxol-5-yl-butyryl)-piperidine-2-carboxylic acid (R)-1-(3-carboxymethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propyl ester | CHEMBL324646 |
Type | Small organic molecule |
Emp. Form. | C36H41NO10 |
Mol. Mass. | 647.7114 |
SMILES | CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(O)=O)c1)c1ccc2OCOc2c1 |
Structure |
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