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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50132981 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_123678 (CHEMBL728561) | ||
| IC50 | 24±n/a nM | ||
| Citation |  Sawyer, JS; Anderson, BD; Beight, DW; Campbell, RM; Jones, ML; Herron, DK; Lampe, JW; McCowan, JR; McMillen, WT; Mort, N; Parsons, S; Smith, EC; Vieth, M; Weir, LC; Yan, L; Zhang, F; Yingling, JM Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem46:3953-6 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50132981 | |||
| n/a | |||
| Name | BDBM50132981 | ||
| Synonyms: | 4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline | CHEMBL129153 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H16N4 | ||
| Mol. Mass. | 300.3571 | ||
| SMILES | Cc1[nH]nc(c1-c1ccnc2ccccc12)-c1cccc(C)n1 |(7.05,-2.76,;8.52,-3.22,;9.75,-2.33,;11,-3.22,;10.52,-4.69,;8.98,-4.69,;8.07,-5.94,;8.7,-7.35,;7.79,-8.59,;6.25,-8.42,;5.65,-7.02,;4.11,-6.86,;3.5,-5.44,;4.41,-4.2,;5.94,-4.37,;6.55,-5.78,;11.43,-5.94,;10.79,-7.34,;11.69,-8.59,;13.22,-8.42,;13.85,-7.02,;15.34,-6.6,;12.94,-5.78,)| | ||
| Structure | 
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