| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
|---|
| Ligand | BDBM50137854 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_196372 |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Summa, V; Petrocchi, A; Pace, P; Matassa, VG; De Francesco, R; Altamura, S; Tomei, L; Koch, U; Neuner, P Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem47:14-7 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Reverse transcriptase/RNaseH |
|---|
| Name: | Reverse transcriptase/RNaseH |
|---|
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 65229.15 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_1473730 |
|---|
| Residue: | 566 |
|---|
| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
|---|
| BDBM50137854 |
|---|
| n/a |
|---|
| Name | BDBM50137854 |
|---|
| Synonyms: | (Z)-4-[3-(3,5-Dichloro-2-cyano-benzyloxy)-phenyl]-2-hydroxy-4-oxo-but-2-enoic acid | CHEMBL174719 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11Cl2NO5 |
|---|
| Mol. Mass. | 392.19 |
|---|
| SMILES | OC(=O)C(=O)CC(=O)c1cccc(OCc2cc(Cl)cc(Cl)c2C#N)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
