| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
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| Ligand | BDBM50138586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_70977 |
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| IC50 | 300±n/a nM |
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| Citation |  Ho, KK; Appell, KC; Baldwin, JJ; Bohnstedt, AC; Dong, G; Guo, T; Horlick, R; Islam, KR; Kultgen, SG; Masterson, CM; McDonald, E; McMillan, K; Morphy, JR; Rankovic, Z; Sundaram, H; Webb, M 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors. Bioorg Med Chem Lett14:545-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 2 |
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| Name: | Sodium- and chloride-dependent glycine transporter 2 |
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| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87438.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
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| Residue: | 797 |
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| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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| BDBM50138586 |
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| n/a |
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| Name | BDBM50138586 |
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| Synonyms: | 2-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-N-((Z)-4-phenyl-but-3-enyl)-benzamide | CHEMBL433739 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N2O2 |
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| Mol. Mass. | 400.5127 |
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| SMILES | Oc1ccc(CCNCc2ccccc2C(=O)NCC\C=C/c2ccccc2)cc1 |
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| Structure | 
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