| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50138879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48338 (CHEMBL663327) |
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| IC50 | 12±n/a nM |
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| Citation |  Tavares, FX; Boncek, V; Deaton, DN; Hassell, AM; Long, ST; Miller, AB; Payne, AA; Miller, LR; Shewchuk, LM; Wells-Knecht, K; Willard, DH; Wright, LL; Zhou, HQ Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k. J Med Chem47:588-99 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_RAT | Ctsk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36798.82 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_633322 |
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| Residue: | 329 |
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| Sequence: | MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVH
NLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSID
YRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGG
YMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVA
RVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGE
SWGNKGYVLLARNKNNACGITNLASFPKM
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| BDBM50138879 |
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| n/a |
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| Name | BDBM50138879 |
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| Synonyms: | CHEMBL345982 | [(S)-1-(5-Phenyl-1H-pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34N4O4 |
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| Mol. Mass. | 442.5512 |
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| SMILES | CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc(n[nH]1)-c1ccccc1 |
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| Structure | 
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