| Reaction Details |
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 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Ligand | BDBM50573307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119416 (CHEMBL4828482) |
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| EC50 | 5.0±n/a nM |
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| Citation |  Wong, ILK; Zhu, X; Chan, KF; Liu, Z; Chan, CF; Chow, TS; Chong, TC; Law, MC; Cui, J; Chow, LMC; Chan, TH Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2). J Med Chem64:14311-14331 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
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| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
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| Mol. Mass.: | 72329.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNQ0 |
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| Residue: | 655 |
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| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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| BDBM50573307 |
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| n/a |
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| Name | BDBM50573307 |
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| Synonyms: | CHEMBL4857228 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H37N3O4 |
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| Mol. Mass. | 455.5897 |
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| SMILES | [H][C@@]12Cc3c([nH]c4cc(OC)ccc34)[C@H](CC(C)C)N1C[C@H](CCC(=O)OC(C)(C)C)NC2=O |r| |
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| Structure | 
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