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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 2 | ||
| Ligand | BDBM50141828 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_70635 | ||
| IC50 | 3400±n/a nM | ||
| Citation |  Shimizu, T; Fujiwara, Y; Osawa, T; Sakai, T; Kubo, K; Kubo, K; Nishitoba, T; Kimura, K; Senga, T; Murooka, H; Iwai, A; Fukushima, K; Yoshino, T; Miwa, A Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors. Bioorg Med Chem Lett14:875-9 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 2 | |||
| Name: | Fibroblast growth factor receptor 2 | ||
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92015.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21802 | ||
| Residue: | 821 | ||
| Sequence: |
| ||
| BDBM50141828 | |||
| n/a | |||
| Name | BDBM50141828 | ||
| Synonyms: | (4-tert-Butyl-cyclohexyl)-[4-(6,7-dimethoxy-quinolin-4-yloxy)-phenyl]-amine | CHEMBL352534 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H34N2O3 | ||
| Mol. Mass. | 434.5705 | ||
| SMILES | COc1cc2nccc(Oc3ccc(NC4CCC(CC4)C(C)(C)C)cc3)c2cc1OC |(1.64,-5.73,;2.98,-6.5,;4.31,-5.73,;5.66,-6.49,;6.98,-5.73,;8.31,-6.49,;9.65,-5.73,;9.65,-4.19,;8.31,-3.42,;8.31,-1.89,;9.64,-1.12,;9.64,.43,;10.96,1.2,;12.3,.43,;13.64,1.21,;14.98,.44,;16.3,1.23,;17.65,.46,;17.67,-1.08,;16.32,-1.86,;14.99,-1.09,;19.03,-1.85,;20.39,-2.59,;19.79,-.49,;18.28,-3.2,;12.3,-1.12,;10.96,-1.89,;6.98,-4.19,;5.66,-3.42,;4.31,-4.19,;2.98,-3.42,;1.65,-4.2,)| | ||
| Structure | 
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