Found 109 hits with Last Name = 'osawa' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3032
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184857
(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O5/c1-16-6-4-5-7-19(16)25(30)29-26(31)28-17-8-10-18(11-9-17)34-22-12-13-27-21-15-24(33-3)23(32-2)14-20(21)22/h4-15H,1-3H3,(H2,28,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184863
(CHEMBL202919 | N-(2-Chlorobenzoyl)-N'-{4-[(6,7-dim...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4Cl)cc3)c2cc1OC Show InChI InChI=1S/C25H20ClN3O4S/c1-31-22-13-18-20(14-23(22)32-2)27-12-11-21(18)33-16-9-7-15(8-10-16)28-25(34)29-24(30)17-5-3-4-6-19(17)26/h3-14H,1-2H3,(H2,28,29,30,34) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184860
(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20N2O5/c1-28-22-14-19-20(15-23(22)29-2)25-13-12-21(19)30-18-10-8-16(9-11-18)26-24(27)31-17-6-4-3-5-7-17/h3-15H,1-2H3,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184858
(CHEMBL425935 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NCCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C26H31N3O4/c1-31-24-16-21-22(17-25(24)32-2)27-15-13-23(21)33-20-10-8-19(9-11-20)29-26(30)28-14-12-18-6-4-3-5-7-18/h8-11,13,15-18H,3-7,12,14H2,1-2H3,(H2,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184864
(CHEMBL203279 | N-{4-[(6,7-Dimethoxy-4-quinazolinyl...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C25H22N4O5/c1-15-6-4-5-7-18(15)23(30)29-25(31)28-16-8-10-17(11-9-16)34-24-19-12-21(32-2)22(33-3)13-20(19)26-14-27-24/h4-14H,1-3H3,(H2,28,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184861
(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C23H26N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H2,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184857
(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O5/c1-16-6-4-5-7-19(16)25(30)29-26(31)28-17-8-10-18(11-9-17)34-22-12-13-27-21-15-24(33-3)23(32-2)14-20(21)22/h4-15H,1-3H3,(H2,28,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell by transactivation enzyme assay |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184868
(CHEMBL378489 | N-Benzoyl-N'-{4-[(6,7-dimethoxy-4-q...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C25H21N3O4S/c1-30-22-14-19-20(15-23(22)31-2)26-13-12-21(19)32-18-10-8-17(9-11-18)27-25(33)28-24(29)16-6-4-3-5-7-16/h3-15H,1-2H3,(H2,27,28,29,33) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184856
(CHEMBL204225 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NCCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C25H30N4O4/c1-31-22-14-20-21(15-23(22)32-2)27-16-28-24(20)33-19-10-8-18(9-11-19)29-25(30)26-13-12-17-6-4-3-5-7-17/h8-11,14-17H,3-7,12-13H2,1-2H3,(H2,26,29,30) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184870
(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H27N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184859
(CHEMBL204120 | N-Cyclohexylcarbonyl-N'-{4-[(6,7-di...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)C4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C25H27N3O4S/c1-30-22-14-19-20(15-23(22)31-2)26-13-12-21(19)32-18-10-8-17(9-11-18)27-25(33)28-24(29)16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,27,28,29,33) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184867
(2-Cyclohexylethyl N-{4-[(6,7-Dimethoxy-4-quinolyl)...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)OCCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C26H30N2O5/c1-30-24-16-21-22(17-25(24)31-2)27-14-12-23(21)33-20-10-8-19(9-11-20)28-26(29)32-15-13-18-6-4-3-5-7-18/h8-12,14,16-18H,3-7,13,15H2,1-2H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184860
(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H20N2O5/c1-28-22-14-19-20(15-23(22)29-2)25-13-12-21(19)30-18-10-8-16(9-11-18)26-24(27)31-17-6-4-3-5-7-17/h3-15H,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184870
(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H27N3O4/c1-29-22-14-19-20(15-23(22)30-2)25-13-12-21(19)31-18-10-8-17(9-11-18)27-24(28)26-16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141817
(CHEMBL171509 | [1-(2-{4-[4-(4-tert-Butyl-phenylami...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCN1CCC(CO)CC1 Show InChI InChI=1S/C34H41N3O4/c1-34(2,3)25-5-7-26(8-6-25)36-27-9-11-28(12-10-27)41-31-13-16-35-30-22-33(32(39-4)21-29(30)31)40-20-19-37-17-14-24(23-38)15-18-37/h5-13,16,21-22,24,36,38H,14-15,17-20,23H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184861
(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C23H26N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184869
(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O4S/c1-31-23-15-20-21(16-24(23)32-2)27-13-12-22(20)33-19-10-8-18(9-11-19)28-26(34)29-25(30)14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,28,29,30,34) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta (PDGF beta-R) |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184866
(CHEMBL382399 | N-Cyclohexylmethyl-N'-{4-[(6,7-dime...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=S)NCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H28N4O3S/c1-29-21-12-19-20(13-22(21)30-2)26-15-27-23(19)31-18-10-8-17(9-11-18)28-24(32)25-14-16-6-4-3-5-7-16/h8-13,15-16H,3-7,14H2,1-2H3,(H2,25,28,32) | PDB
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| Article
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184865
(1-cyclohexyl-3-(4-(6,7-dimethoxyquinolin-4-yloxy)p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H27N3O3S/c1-28-22-14-19-20(15-23(22)29-2)25-13-12-21(19)30-18-10-8-17(9-11-18)27-24(31)26-16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,26,27,31) | PDB
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141829
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)c2cc1OC Show InChI InChI=1S/C27H28N2O3/c1-27(2,3)18-6-8-19(9-7-18)29-20-10-12-21(13-11-20)32-24-14-15-28-23-17-26(31-5)25(30-4)16-22(23)24/h6-17,29H,1-5H3 | PDB
MMDB
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PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50184862
(CHEMBL204409 | N-Benzyl-N'-{4-[(6,7-dimethoxy-4-qu...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=S)NCc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H22N4O3S/c1-29-21-12-19-20(13-22(21)30-2)26-15-27-23(19)31-18-10-8-17(9-11-18)28-24(32)25-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H2,25,28,32) | PDB
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141822
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3F)c2cc1OC Show InChI InChI=1S/C27H27FN2O3/c1-27(2,3)17-6-8-18(9-7-17)30-19-10-11-24(21(28)14-19)33-23-12-13-29-22-16-26(32-5)25(31-4)15-20(22)23/h6-16,30H,1-5H3 | PDB
MMDB
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KEGG
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UniChem
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PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141819
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)c(F)c3)c2cc1OC Show InChI InChI=1S/C27H27FN2O3/c1-27(2,3)17-6-8-18(9-7-17)30-22-11-10-19(14-21(22)28)33-24-12-13-29-23-16-26(32-5)25(31-4)15-20(23)24/h6-16,30H,1-5H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184865
(1-cyclohexyl-3-(4-(6,7-dimethoxyquinolin-4-yloxy)p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H27N3O3S/c1-28-22-14-19-20(15-23(22)29-2)25-13-12-21(19)30-18-10-8-17(9-11-18)27-24(31)26-16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,26,27,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141812
(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-2-fluoro-phe...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3F)ccnc2cc1OCCNCCO Show InChI InChI=1S/C30H34FN3O4/c1-30(2,3)20-5-7-21(8-6-20)34-22-9-10-27(24(31)17-22)38-26-11-12-33-25-19-29(28(36-4)18-23(25)26)37-16-14-32-13-15-35/h5-12,17-19,32,34-35H,13-16H2,1-4H3 | PDB
MMDB
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KEGG
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| CHEMBL
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UniChem
Similars
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PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | MMDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of platelet-derived growth factor receptor (PDGF-R) in human aortic smooth muscle cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50290838
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | CH...)Show InChI InChI=1S/C16H13BrN2O3/c1-20-14-7-12-13(8-15(14)21-2)18-9-19-16(12)22-11-5-3-4-10(17)6-11/h3-9H,1-2H3 | PDB
MMDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141823
(2-[(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCN(CCO)CCO Show InChI InChI=1S/C32H39N3O5/c1-32(2,3)23-5-7-24(8-6-23)34-25-9-11-26(12-10-25)40-29-13-14-33-28-22-31(30(38-4)21-27(28)29)39-20-17-35(15-18-36)16-19-37/h5-14,21-22,34,36-37H,15-20H2,1-4H3 | PDB
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UniChem
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PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141813
(1-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-meth...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCC(O)CN1CCOCC1 Show InChI InChI=1S/C33H39N3O5/c1-33(2,3)23-5-7-24(8-6-23)35-25-9-11-27(12-10-25)41-30-13-14-34-29-20-32(31(38-4)19-28(29)30)40-22-26(37)21-36-15-17-39-18-16-36/h5-14,19-20,26,35,37H,15-18,21-22H2,1-4H3 | PDB
MMDB
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| CHEMBL
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PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184867
(2-Cyclohexylethyl N-{4-[(6,7-Dimethoxy-4-quinolyl)...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)OCCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C26H30N2O5/c1-30-24-16-21-22(17-25(24)31-2)27-14-12-23(21)33-20-10-8-19(9-11-20)28-26(29)32-15-13-18-6-4-3-5-7-18/h8-12,14,16-18H,3-7,13,15H2,1-2H3,(H,28,29) | PDB
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PC sid
UniChem
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PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141809
(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCNCCO Show InChI InChI=1S/C30H35N3O4/c1-30(2,3)21-5-7-22(8-6-21)33-23-9-11-24(12-10-23)37-27-13-14-32-26-20-29(28(35-4)19-25(26)27)36-18-16-31-15-17-34/h5-14,19-20,31,33-34H,15-18H2,1-4H3 | PDB
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PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation in intact cells |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141809
(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCNCCO Show InChI InChI=1S/C30H35N3O4/c1-30(2,3)21-5-7-22(8-6-21)33-23-9-11-24(12-10-23)37-27-13-14-32-26-20-29(28(35-4)19-25(26)27)36-18-16-31-15-17-34/h5-14,19-20,31,33-34H,15-18H2,1-4H3 | PDB
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| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM13530
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) | PDB
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Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR alpha phosphorylation in G292 cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141810
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)c(C)c3)c2cc1OC Show InChI InChI=1S/C28H30N2O3/c1-18-15-21(11-12-23(18)30-20-9-7-19(8-10-20)28(2,3)4)33-25-13-14-29-24-17-27(32-6)26(31-5)16-22(24)25/h7-17,30H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
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| CHEMBL
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UniChem
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PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50141809
(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCNCCO Show InChI InChI=1S/C30H35N3O4/c1-30(2,3)21-5-7-22(8-6-21)33-23-9-11-24(12-10-23)37-27-13-14-32-26-20-29(28(35-4)19-25(26)27)36-18-16-31-15-17-34/h5-14,19-20,31,33-34H,15-18H2,1-4H3 | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-Kit autophosphorylation in intact cells |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Rattus norvegicus) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141832
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)c(C)c3C)c2cc1OC Show InChI InChI=1S/C29H32N2O3/c1-18-19(2)25(13-12-23(18)31-21-10-8-20(9-11-21)29(3,4)5)34-26-14-15-30-24-17-28(33-7)27(32-6)16-22(24)26/h8-17,31H,1-7H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Homo sapiens (Human)) | BDBM50290834
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) in A431 cells. |
Bioorg Med Chem Lett 7: 2935-2940 (1997)
Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184866
(CHEMBL382399 | N-Cyclohexylmethyl-N'-{4-[(6,7-dime...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=S)NCC4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C24H28N4O3S/c1-29-21-12-19-20(13-22(21)30-2)26-15-27-23(19)31-18-10-8-17(9-11-18)28-24(32)25-14-16-6-4-3-5-7-16/h8-13,15-16H,3-7,14H2,1-2H3,(H2,25,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141821
((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)Show SMILES COc1cc2nccc(Oc3ccc(cc3)C(=O)c3ccc(cc3)C(C)(C)C)c2cc1OC Show InChI InChI=1S/C28H27NO4/c1-28(2,3)20-10-6-18(7-11-20)27(30)19-8-12-21(13-9-19)33-24-14-15-29-23-17-26(32-5)25(31-4)16-22(23)24/h6-17H,1-5H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141824
((4-tert-Butyl-phenyl)-{4-[6-methoxy-7-(2-morpholin...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCN1CCOCC1 Show InChI InChI=1S/C32H37N3O4/c1-32(2,3)23-5-7-24(8-6-23)34-25-9-11-26(12-10-25)39-29-13-14-33-28-22-31(30(36-4)21-27(28)29)38-20-17-35-15-18-37-19-16-35/h5-14,21-22,34H,15-20H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141816
(1-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-meth...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCC(O)CN1CCCCC1 Show InChI InChI=1S/C34H41N3O4/c1-34(2,3)24-8-10-25(11-9-24)36-26-12-14-28(15-13-26)41-31-16-17-35-30-21-33(32(39-4)20-29(30)31)40-23-27(38)22-37-18-6-5-7-19-37/h8-17,20-21,27,36,38H,5-7,18-19,22-23H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141814
(CHEMBL276125 | [4-(6,7-Dimethoxy-quinolin-4-yloxy)...)Show SMILES COc1cc2nccc(Oc3ccc(Nc4ccc(cc4)C(C)C)cc3)c2cc1OC Show InChI InChI=1S/C26H26N2O3/c1-17(2)18-5-7-19(8-6-18)28-20-9-11-21(12-10-20)31-24-13-14-27-23-16-26(30-4)25(29-3)15-22(23)24/h5-17,28H,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184869
(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O4S/c1-31-23-15-20-21(16-24(23)32-2)27-13-12-22(20)33-19-10-8-18(9-11-19)28-26(34)29-25(30)14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,28,29,30,34) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 202 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM13530
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) | PDB
UniProtKB/SwissProt
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| Purchase
CHEMBL
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MCE
MMDB
PC cid
PC sid
PDB
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Patents
Similars
| Article
PubMed
| n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184859
(CHEMBL204120 | N-Cyclohexylcarbonyl-N'-{4-[(6,7-di...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)C4CCCCC4)cc3)c2cc1OC Show InChI InChI=1S/C25H27N3O4S/c1-30-22-14-19-20(15-23(22)31-2)26-13-12-21(19)32-18-10-8-17(9-11-18)27-25(33)28-24(29)16-6-4-3-5-7-16/h8-16H,3-7H2,1-2H3,(H2,27,28,29,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 233 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50184857
(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC Show InChI InChI=1S/C26H23N3O5/c1-16-6-4-5-7-19(16)25(30)29-26(31)28-17-8-10-18(11-9-17)34-22-12-13-27-21-15-24(33-3)23(32-2)14-20(21)22/h4-15H,1-3H3,(H2,28,29,30,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 234 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of c-kit receptor phosphorylation in M07e cell by transactivation enzyme assay |
J Med Chem 49: 2186-92 (2006)
Article DOI: 10.1021/jm0506423
BindingDB Entry DOI: 10.7270/Q2NC60TB |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50141811
(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-3-fluoro-phe...)Show SMILES COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)c(F)c3)ccnc2cc1OCCNCCO Show InChI InChI=1S/C30H34FN3O4/c1-30(2,3)20-5-7-21(8-6-20)34-25-10-9-22(17-24(25)31)38-27-11-12-33-26-19-29(28(36-4)18-23(26)27)37-16-14-32-13-15-35/h5-12,17-19,32,34-35H,13-16H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line |
Bioorg Med Chem Lett 14: 875-9 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV |
More data for this
Ligand-Target Pair | |
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