Ki Summary

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Target

G-protein coupled receptor 35

Ligand

BDBM50575546

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2125630 (CHEMBL4834975)

IC50

27±n/a nM

Citation

Wei, L; Hou, T; Li, J; Zhang, X; Zhou, H; Wang, Z; Cheng, J; Xiang, K; Wang, J; Zhao, Y; Liang, X Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. J Med Chem64:2634-2647 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

G-protein coupled receptor 35

Name:

G-protein coupled receptor 35

Synonyms:

G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

34085.57

Organism:

Homo sapiens (Human)

Description:

gi_33695097

Residue:

309

Sequence:

MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA

BDBM50575546

n/a

Name

BDBM50575546

Synonyms:

CHEMBL4871203

Type

Small organic molecule

Emp. Form.

C21H12O9

Mol. Mass.

408.3146

SMILES

COc1ccccc1-c1c2oc(=O)c(cc2cc2cc(C(O)=O)c(=O)oc12)C(O)=O |(35.47,-5.72,;34.13,-6.49,;32.8,-5.73,;32.79,-4.19,;31.46,-3.42,;30.12,-4.21,;30.13,-5.74,;31.47,-6.5,;31.48,-8.04,;32.81,-8.8,;34.15,-8.03,;35.48,-8.8,;36.82,-8.04,;35.48,-10.35,;34.14,-11.12,;32.81,-10.35,;31.48,-11.12,;30.15,-10.35,;28.81,-11.12,;27.48,-10.34,;26.14,-11.1,;24.81,-10.33,;26.13,-12.64,;27.49,-8.79,;26.16,-8.02,;28.83,-8.03,;30.16,-8.81,;36.82,-11.13,;36.81,-12.67,;38.15,-10.36,)|

Structure