| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
|---|
| Ligand | BDBM50575768 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2125968 (CHEMBL4835313) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Schaffner, AP; Sansilvestri-Morel, P; Despaux, N; Ruano, E; Persigand, T; Rupin, A; Mennecier, P; Vallez, MO; Raimbaud, E; Desos, P; Gloanec, P Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem64:3897-3910 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carboxypeptidase B2 |
|---|
| Name: | Carboxypeptidase B2 |
|---|
| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48432.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96IY4 |
|---|
| Residue: | 423 |
|---|
| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
|
|
|
|---|
| BDBM50575768 |
|---|
| n/a |
|---|
| Name | BDBM50575768 |
|---|
| Synonyms: | CHEMBL4846664 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H28N3O4P |
|---|
| Mol. Mass. | 417.4385 |
|---|
| SMILES | NCCCCC1(CN(Cc2ccccc2-c2cccnc2)CCP1(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
