| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-2 |
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| Ligand | BDBM50576018 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2126195 (CHEMBL4835540) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Konteatis, Z; Travins, J; Gross, S; Marjon, K; Barnett, A; Mandley, E; Nicolay, B; Nagaraja, R; Chen, Y; Sun, Y; Liu, Z; Yu, J; Ye, Z; Jiang, F; Wei, W; Fang, C; Gao, Y; Kalev, P; Hyer, ML; DeLaBarre, B; Jin, L; Padyana, AK; Dang, L; Murtie, J; Biller, SA; Sui, Z; Marks, KM Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous J Med Chem64:4430-4449 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
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| Type: | Protein |
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| Mol. Mass.: | 43659.65 |
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| Organism: | Human |
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| Description: | P31153 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM50576018 |
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| n/a |
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| Name | BDBM50576018 |
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| Synonyms: | CHEMBL4585665 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25N5O3 |
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| Mol. Mass. | 479.5298 |
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| SMILES | COc1ccc(cc1)-c1c(Nc2ccon2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1 |t:35| |
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| Structure | 
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