| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50144430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86826 (CHEMBL694697) |
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| IC50 | 440±n/a nM |
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| Citation |  Brown, MF; Avery, M; Brissette, WH; Chang, JH; Colizza, K; Conklyn, M; DiRico, AP; Gladue, RP; Kath, JC; Krueger, SS; Lira, PD; Lillie, BM; Lundquist, GD; Mairs, EN; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Rossulek, MI; Shepard, RM; Sims, J; Strelevitz, TJ; Truesdell, S; Tylaska, LA; Yoon, K; Zheng, D Novel CCR1 antagonists with improved metabolic stability. Bioorg Med Chem Lett14:2175-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50144430 |
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| n/a |
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| Name | BDBM50144430 |
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| Synonyms: | CHEMBL65784 | Quinoxaline-2-carboxylic acid ((1S,2S)-1-benzyl-4-benzylcarbamoyl-7-fluoro-2-hydroxy-7-methyl-octyl)-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C33H37FN4O3 |
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| Mol. Mass. | 556.6703 |
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| SMILES | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 |
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| Structure | 
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