Reaction Details |
| Report a problem with these data |
Target | Ribosomal protein S6 kinase alpha-6 |
---|
Ligand | BDBM25017 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2131822 (CHEMBL4841337) |
---|
IC50 | 15±n/a nM |
---|
Citation | Yuan, Y; Xu, J; Jiang, L; Yu, K; Ge, Y; Li, M; He, H; Niu, Q; Shi, X; Fan, L; Chen, Z; Zhao, Z; Li, S; Xu, Y; Wang, Z; Li, H Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. J Med Chem64:13572-13587 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ribosomal protein S6 kinase alpha-6 |
---|
Name: | Ribosomal protein S6 kinase alpha-6 |
Synonyms: | 90 kDa ribosomal protein S6 kinase 6 | KS6A6_HUMAN | RPS6KA6 | RPS6KA6(Kin.Dom.1 - N-terminal) | RPS6KA6(Kin.Dom.2 - C-terminal) | RSK-4 | RSK4 | Ribosomal S6 Kinase 4 (RSK-4) | Ribosomal S6 kinase 4 | Ribosomal protein S6 kinase alpha 6 | Ribosomal protein S6 kinase alpha 6 (RSK4) | Ribosomal protein S6 kinase alpha-6 | S6K-alpha 6 | p90-RSK 6 | p90RSK | pp90RSK4 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 83868.06 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 745 |
Sequence: | MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH
VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT
KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA
ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM
APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA
QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF
DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA
QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI
ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV
HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD
AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL
SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ
PVLEPVAASSLAQRRSMKKRTSTGL
|
|
|
BDBM25017 |
---|
n/a |
---|
Name | BDBM25017 |
Synonyms: | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one | BI-D1870 | US11851436, Compound BI-D1870 |
Type | Small organic molecule |
Emp. Form. | C19H23F2N5O2 |
Mol. Mass. | 391.415 |
SMILES | CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 |
Structure |
|