Reaction Details |
| Report a problem with these data |
Target | Endothelin-1 receptor |
---|
Ligand | BDBM50146730 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_65482 (CHEMBL682357) |
---|
IC50 | 2.5±n/a nM |
---|
Citation | Bolli, MH; Marfurt, J; Grisostomi, C; Boss, C; Binkert, C; Hess, P; Treiber, A; Thorin, E; Morrison, K; Buchmann, S; Bur, D; Ramuz, H; Clozel, M; Fischli, W; Weller, T Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists. J Med Chem47:2776-95 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin-1 receptor |
---|
Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
BDBM50146730 |
---|
n/a |
---|
Name | BDBM50146730 |
Synonyms: | (S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-[(S)-2-oxo-5-phenyl-1-(4-trifluoromethoxy-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl]-acetic acid | CHEMBL91873 |
Type | Small organic molecule |
Emp. Form. | C31H27F3N4O5 |
Mol. Mass. | 592.5651 |
SMILES | Cc1cc(C)nc(O[C@H](C(O)=O)[C@]2(NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc23)c2ccccc2)n1 |
Structure |
|