| Reaction Details |
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 | Report a problem with these data |
| Target | Myc proto-oncogene protein |
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| Ligand | BDBM445515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2145528 (CHEMBL5029808) |
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| IC50 | 3.4±n/a nM |
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| Citation |  Hill, MD; Quesnelle, C; Tokarski, J; Fang, H; Fanslau, C; Haarhoff, Z; Kramer, M; Madari, S; Wiebesiek, A; Morrison, J; Simmermacher-Mayer, J; Sinz, M; Westhouse, R; Xie, C; Zhao, J; Huang, L; Sheriff, S; Yan, C; Marsilio, F; Everlof, G; Zvyaga, T; Lee, F; Gavai, AV; Degnan, AP Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg Med Chem Lett51:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myc proto-oncogene protein |
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| Name: | Myc proto-oncogene protein |
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| Synonyms: | BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48794.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935266 |
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| Residue: | 439 |
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| Sequence: | MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA
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| BDBM445515 |
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| n/a |
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| Name | BDBM445515 |
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| Synonyms: | 2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-9-fluoro-5-[(S)-oxan-4-yl(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl]propan-2-ol | US10683290, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32FN5O2 |
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| Mol. Mass. | 513.6058 |
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| SMILES | Cc1nnn(C)c1-c1cc(F)c2c(c1)n([C@@H](C1CCOCC1)c1ccccc1)c1cc(cnc21)C(C)(C)O |r| |
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| Structure | 
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