Ki Summary

Reaction Details

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Target

Myc proto-oncogene protein

Ligand

BDBM445527

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2145528 (CHEMBL5029808)

IC50

0.800000±n/a nM

Citation

Hill, MD; Quesnelle, C; Tokarski, J; Fang, H; Fanslau, C; Haarhoff, Z; Kramer, M; Madari, S; Wiebesiek, A; Morrison, J; Simmermacher-Mayer, J; Sinz, M; Westhouse, R; Xie, C; Zhao, J; Huang, L; Sheriff, S; Yan, C; Marsilio, F; Everlof, G; Zvyaga, T; Lee, F; Gavai, AV; Degnan, AP Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg Med Chem Lett51:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Myc proto-oncogene protein

Name:

Myc proto-oncogene protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

48794.95

Organism:

Homo sapiens (Human)

Description:

ChEMBL_935266

Residue:

439

Sequence:

MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA

BDBM445527

n/a

Name

BDBM445527

Synonyms:

2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-oxan-4-yl(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl]propan-2-ol | US10683290, Example 19

Type

Small organic molecule

Emp. Form.

C30H32FN5O2

Mol. Mass.

513.6058

SMILES

Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cc1F)C(C)(C)O |r,wU:11.11,(5.87,4.1,;5.87,2.56,;7.24,1.86,;7,.34,;5.48,.1,;4.71,-1.23,;4.78,1.47,;3.3,1.87,;2.27,.73,;.76,1.05,;-.49,.14,;-.49,-1.4,;.85,-2.17,;2.18,-1.4,;3.51,-2.17,;3.51,-3.71,;2.18,-4.48,;.85,-3.71,;-1.82,-2.17,;-3.15,-1.4,;-4.49,-2.17,;-4.49,-3.71,;-3.15,-4.48,;-1.82,-3.71,;-1.73,1.05,;-3.24,.73,;-4.27,1.87,;-3.79,3.33,;-2.29,3.65,;-1.26,2.51,;.28,2.51,;1.31,3.65,;2.82,3.33,;3.85,4.48,;-5.76,1.47,;-6.85,2.56,;-6.16,-.02,;-7.24,1.07,)|

Structure