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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Myc proto-oncogene protein | ||
| Ligand | BDBM445584 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2145528 (CHEMBL5029808) | ||
| IC50 | 42±n/a nM | ||
| Citation |  Hill, MD; Quesnelle, C; Tokarski, J; Fang, H; Fanslau, C; Haarhoff, Z; Kramer, M; Madari, S; Wiebesiek, A; Morrison, J; Simmermacher-Mayer, J; Sinz, M; Westhouse, R; Xie, C; Zhao, J; Huang, L; Sheriff, S; Yan, C; Marsilio, F; Everlof, G; Zvyaga, T; Lee, F; Gavai, AV; Degnan, AP Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg Med Chem Lett51:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Myc proto-oncogene protein | |||
| Name: | Myc proto-oncogene protein | ||
| Synonyms: | BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 48794.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_935266 | ||
| Residue: | 439 | ||
| Sequence: |
| ||
| BDBM445584 | |||
| n/a | |||
| Name | BDBM445584 | ||
| Synonyms: | US10683290, Example 77 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H32ClN5O2 | ||
| Mol. Mass. | 530.06 | ||
| SMILES | Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cc1Cl)C(C)(C)O |r,wD:11.11,(4.65,-1.19,;5.42,.14,;6.95,.3,;7.27,1.81,;5.94,2.58,;6.34,4.07,;4.79,1.55,;3.29,1.87,;2.26,.73,;.75,1.05,;-.5,.14,;-.5,-1.4,;-1.83,-2.17,;-3.16,-1.4,;-4.5,-2.17,;-4.5,-3.71,;-3.16,-4.48,;-1.83,-3.71,;.84,-2.17,;.84,-3.71,;2.17,-4.48,;3.51,-3.71,;3.51,-2.17,;2.17,-1.4,;-1.74,1.05,;-3.25,.73,;-4.28,1.87,;-3.8,3.33,;-2.3,3.65,;-1.27,2.51,;.27,2.51,;1.31,3.65,;2.81,3.33,;3.84,4.48,;-5.78,1.55,;-6.81,2.69,;-7.27,1.15,;-6.26,.09,)| | ||
| Structure | 
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