Reaction Details | |||
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Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50433561 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2145775 (CHEMBL5030055) | ||
Ki | 0.880000±n/a nM | ||
Citation | Reutershan, MH; Machacek, MR; Altman, MD; Bogen, S; Cai, M; Cammarano, C; Chen, D; Christopher, M; Cryan, J; Daublain, P; Fradera, X; Geda, P; Goldenblatt, P; Hill, AD; Kemper, RA; Kutilek, V; Li, C; Martinez, M; McCoy, M; Nair, L; Pan, W; Thompson, CF; Scapin, G; Shizuka, M; Spatz, ML; Steinhuebel, D; Sun, B; Voss, ME; Wang, X; Yang, L; Yeh, TC; Dussault, I; Marshall, CG; Trotter, BW Discovery of J Med Chem64:16213-16241 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
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BDBM50433561 | |||
n/a | |||
Name | BDBM50433561 | ||
Synonyms: | CHEMBL2381408 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H34Cl2FN3O3 | ||
Mol. Mass. | 562.503 | ||
SMILES | CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:8.8,5.4,31.34,wD:17.29,7.31,34.38,(40.88,-57.18,;39.34,-57.18,;38.57,-58.51,;40.11,-58.5,;38.57,-55.84,;37.04,-55.84,;37.52,-54.37,;36.27,-53.47,;35.03,-54.37,;33.51,-54.09,;32.52,-55.27,;31.01,-54.99,;30.49,-53.53,;31.49,-52.36,;30.98,-50.9,;33,-52.64,;34.01,-51.48,;35.49,-55.84,;36.38,-57.1,;37.93,-57.11,;35.48,-58.34,;34.01,-57.86,;32.69,-58.61,;31.36,-57.84,;30.03,-58.6,;31.37,-56.3,;32.71,-55.54,;34.03,-56.32,;36.26,-51.93,;34.93,-51.16,;37.6,-51.15,;37.6,-49.61,;36.26,-48.86,;36.26,-47.31,;37.6,-46.54,;37.6,-45,;38.93,-47.32,;38.93,-48.85,)| | ||
Structure |