| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
|---|
| Ligand | BDBM50147244 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_88045 |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Lowe, DB; Magnuson, S; Qi, N; Campbell, AM; Cook, J; Hong, Z; Wang, M; Rodriguez, M; Achebe, F; Kluender, H; Wong, WC; Bullock, WH; Salhanick, AI; Witman-Jones, T; Bowling, ME; Keiper, C; Clairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett14:3155-9 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hormone-sensitive lipase |
|---|
| Name: | Hormone-sensitive lipase |
|---|
| Synonyms: | HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 116599.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q05469 |
|---|
| Residue: | 1076 |
|---|
| Sequence: | MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
|
|
|
|---|
| BDBM50147244 |
|---|
| n/a |
|---|
| Name | BDBM50147244 |
|---|
| Synonyms: | 1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbonyl)-piperidine-4-carboxylic acid ethyl ester | CHEMBL110716 | ethyl 1-(4-isopropyl-3-methyl-5-oxo-2,5-dihydroisoxazole-2-carbonyl)piperidine-4-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H24N2O5 |
|---|
| Mol. Mass. | 324.3722 |
|---|
| SMILES | CCOC(=O)C1CCN(CC1)C(=O)n1oc(=O)c(C(C)C)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
