BindingDB PrimarySearch

Found 530 hits with Last Name = 'campbell' and Initial = 'am'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147315 (2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383860 (US10280150, Cmpd No I-143 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132H mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire hi...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147299 (4-Butyl-3-methyl-2-(4-methyl-piperidine-1-carbonyl...) Show SMILES CCCCc1c(C)n(oc1=O)C(=O)N1CCC(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147297 (4-Isopropyl-2-[4-(3-methoxy-phenyl)-piperazine-1-c...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503280 (CHEMBL4469055 \| US11311527, Cpd ID I-26 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147270 (3-Methyl-4-(2-phenoxy-ethyl)-2-(piperidine-1-carbo...) Show SMILES Cc1c(CCOc2ccccc2)c(=O)on1C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503263 (CHEMBL4464313 \| US11311527, Cpd ID I-23 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503260 (CHEMBL4456610 \| US11311527, Cpd ID I-27 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147243 (4-Isopropyl-3-methyl-2-(piperidine-1-carbonyl)-2H-...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503280 (CHEMBL4469055 \| US11311527, Cpd ID I-26 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132C mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147251 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1cccs1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147281 (4-Isobutyl-3-methyl-2-(4-methyl-piperidine-1-carbo...) Show SMILES CC(C)Cc1c(C)n(oc1=O)C(=O)N1CCC(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147257 (4-(2-Ethoxy-ethyl)-3-methyl-2-(4-methyl-piperidine...) Show SMILES CCOCCc1c(C)n(oc1=O)C(=O)N1CCC(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383860 (US10280150, Cmpd No I-143 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132G mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire hi...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147251 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1cccs1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147279 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1ccccc1F Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50506480 (CHEMBL4437754 \| US11311527, Cpd ID I-20 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147253 (2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-isop...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383892 (US10280150, Cmpd No I-175 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147270 (3-Methyl-4-(2-phenoxy-ethyl)-2-(piperidine-1-carbo...) Show SMILES Cc1c(CCOc2ccccc2)c(=O)on1C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383892 (US10280150, Cmpd No I-175 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503280 (CHEMBL4469055 \| US11311527, Cpd ID I-26 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human Myc-DDK-tagged IDH1 R132C mutant using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrat...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147267 (4-Cyclohexyl-3-methyl-2-(4-methyl-piperidine-1-car...) Show SMILES CC1CCN(CC1)C(=O)n1oc(=O)c(C2CCCCC2)c1C Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147245 (4-Isobutyl-3-methyl-2-(4-phenyl-piperidine-1-carbo...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383860 (US10280150, Cmpd No I-143 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132C mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire hi...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147272 (4-(2-Methoxy-ethyl)-3-methyl-2-(4-m-tolyl-piperidi...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147241 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1ccco1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147248 (4-(2-Methoxy-ethyl)-3-methyl-2-(4-phenyl-piperidin...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147298 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147289 (4-Isobutyl-3-methyl-2-(piperidine-1-carbonyl)-2H-i...) Show SMILES CC(C)Cc1c(C)n(oc1=O)C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147260 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM383860 (US10280150, Cmpd No I-143 \| US10550099, Compound I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132L mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire hi...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147303 (4-Benzyl-3-methyl-2-(piperidine-1-carbonyl)-2H-iso...) Show SMILES Cc1c(Cc2ccccc2)c(=O)on1C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147244 (1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbo...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM377646 (4-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2- \|...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147300 (4-(4-Chloro-phenylsulfanyl)-3-methyl-2-(piperidine...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147283 (4-Isopropyl-3-methyl-2-(4-methyl-piperidine-1-carb...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCC(C)CC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147280 (3-Methyl-2-(4-methyl-piperidine-1-carbonyl)-4-(tet...) Show SMILES CC1CCN(CC1)C(=O)n1oc(=O)c(C2CCSCC2)c1C Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147282 (3-Methyl-4-phenylsulfanyl-2-(piperidine-1-carbonyl...) Show SMILES Cc1c(Sc2ccccc2)c(=O)on1C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503263 (CHEMBL4464313 \| US11311527, Cpd ID I-23 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132C mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50506474 (Ft-2102 \| Olutasidenib \| US11311527, Cpd ID 1 \| US...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human Myc-DDK-tagged IDH1 R132G mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by rapidfire hi...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147234 (4-Isopropyl-3-methyl-2-(4-phenyl-piperazine-1-carb...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147276 (4-Cyclopentyl-3-methyl-2-(piperidine-1-carbonyl)-2...) Show SMILES Cc1c(C2CCCC2)c(=O)on1C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147296 (4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isox...) Show SMILES CCCCc1c(C)n(oc1=O)C(=O)N1CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147271 (4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM50147269 (2-(3,3-Dimethyl-piperidine-1-carbonyl)-4-isopropyl...) Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCCC(C)(C)C1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM377574 (4-{[(1S)-1-(6-chloro-2-oxo- \| US10266495, Compound...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Forma Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometr...				J Med Chem 62: 6575-6596 (2019) Article DOI: 10.1021/acs.jmedchem.9b00362 BindingDB Entry DOI: 10.7270/Q2VD72TR
Forma Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503280 (CHEMBL4469055 \| US11311527, Cpd ID I-26 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human Myc-DDK-tagged IDH1 R132H mutant using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrat...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Homo sapiens (Human))	BDBM50503260 (CHEMBL4456610 \| US11311527, Cpd ID I-27 \| US113762...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human Myc-DDK-tagged IDH1 R132H mutant using alpha-ketoglutarate as substrate preincubated for 15 mins followed by substrat...				J Med Chem 63: 1612-1623 (2020) Article DOI: 10.1021/acs.jmedchem.9b01423 BindingDB Entry DOI: 10.7270/Q2J106F7
FORMA Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

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