| Reaction Details |
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 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
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| Ligand | BDBM50147248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_517 (CHEMBL615539) |
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| IC50 | 5±n/a nM |
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| Citation |  Lowe, DB; Magnuson, S; Qi, N; Campbell, AM; Cook, J; Hong, Z; Wang, M; Rodriguez, M; Achebe, F; Kluender, H; Wong, WC; Bullock, WH; Salhanick, AI; Witman-Jones, T; Bowling, ME; Keiper, C; Clairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett14:3155-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hormone-sensitive lipase |
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| Name: | Hormone-sensitive lipase |
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| Synonyms: | HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 116599.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q05469 |
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| Residue: | 1076 |
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| Sequence: | MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
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| BDBM50147248 |
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| n/a |
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| Name | BDBM50147248 |
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| Synonyms: | 4-(2-Methoxy-ethyl)-3-methyl-2-(4-phenyl-piperidine-1-carbonyl)-2H-isoxazol-5-one | 4-(2-methoxyethyl)-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-one | CHEMBL320249 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N2O4 |
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| Mol. Mass. | 344.4049 |
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| SMILES | COCCc1c(C)n(oc1=O)C(=O)N1CCC(CC1)c1ccccc1 |
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| Structure | 
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