| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 1 |
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| Ligand | BDBM50580900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2149291 (CHEMBL5033689) |
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| IC50 | 600±n/a nM |
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| Citation |  Wang, S; Xu, Y; Zhao, Y; Zhang, S; Li, M; Li, X; He, J; Zhou, H; Ge, Z; Li, R; Yang, B N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem226:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 1 |
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| Name: | Urea transporter 1 |
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| Synonyms: | Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B) |
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| Type: | Protein |
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| Mol. Mass.: | 42037.85 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 384 |
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| Sequence: | MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRG
ISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYN
ATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALS
LYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIF
LCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALT
WQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLS
KVTYSEENRIFYLQNKKRVVDSPL
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| BDBM50580900 |
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| n/a |
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| Name | BDBM50580900 |
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| Synonyms: | CHEMBL5081628 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9N3O5 |
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| Mol. Mass. | 299.2384 |
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| SMILES | [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2ccc(=O)[nH]c2c1 |
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| Structure | 
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