Reaction Details | |||
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Target | Gonadotropin-releasing hormone receptor | ||
Ligand | BDBM50149250 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_71435 (CHEMBL685307) | ||
Ki | 23±n/a nM | ||
Citation | Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Connors, PJ; Gao, Y; Rowbottom, MW; Struthers, RS; Reinhart, GJ; Xie, Q; Chen, TK; Bozigian, H; Killam Bonneville, AL; Fisher, A; Jin, L; Saunders, J; Chen, C 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem47:3483-6 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Gonadotropin-releasing hormone receptor | |||
Name: | Gonadotropin-releasing hormone receptor | ||
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
Type: | Enzyme | ||
Mol. Mass.: | 37749.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30968 | ||
Residue: | 328 | ||
Sequence: |
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BDBM50149250 | |||
n/a | |||
Name | BDBM50149250 | ||
Synonyms: | 3-((R)-2-Cyclohexyl-2-isopropylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL327076 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H36F3N3O3 | ||
Mol. Mass. | 543.6203 | ||
SMILES | COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](NC(C)C)C2CCCCC2)c1=O |wU:26.28,(6.63,1.74,;5.3,.97,;5.3,-.57,;6.65,-1.34,;6.63,-2.89,;5.3,-3.65,;3.97,-2.88,;3.97,-1.34,;2.64,-.57,;2.64,-3.64,;2.64,-5.16,;3.97,-5.93,;1.29,-5.96,;1.29,-7.5,;2.62,-8.26,;2.62,-9.81,;1.29,-10.58,;3.95,-10.58,;5.3,-9.81,;5.3,-8.26,;3.95,-7.47,;5.05,-6.39,;-.04,-5.18,;-.05,-6.68,;-.04,-3.62,;-1.37,-2.85,;-2.7,-3.62,;-4.03,-2.85,;-5.36,-3.62,;-6.7,-2.83,;-5.37,-5.16,;-2.7,-5.16,;-1.37,-5.93,;-1.38,-7.47,;-2.72,-8.24,;-4.05,-7.47,;-4.03,-5.93,;1.31,-2.85,;1.31,-1.31,)| | ||
Structure |