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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein arginine N-methyltransferase 5 | ||
| Ligand | BDBM579047 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2163197 (CHEMBL5048058) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Smith, CR; Aranda, R; Bobinski, TP; Briere, DM; Burns, AC; Christensen, JG; Clarine, J; Engstrom, LD; Gunn, RJ; Ivetac, A; Jean-Baptiste, R; Ketcham, JM; Kobayashi, M; Kuehler, J; Kulyk, S; Lawson, JD; Moya, K; Olson, P; Rahbaek, L; Thomas, NC; Wang, X; Waters, LM; Marx, MA Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5?MTA Complex for the Treatment of J Med Chem65:1749-1766 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein arginine N-methyltransferase 5 | |||
| Name: | Protein arginine N-methyltransferase 5 | ||
| Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72679.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O14744 | ||
| Residue: | 637 | ||
| Sequence: |
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| BDBM579047 | |||
| n/a | |||
| Name | BDBM579047 | ||
| Synonyms: | 2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H- pyrazol-5-yl)-1-naphthonitrile | US11479551, Example 4-147 | US11492351, Example 4-147 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H18N6O | ||
| Mol. Mass. | 406.4393 | ||
| SMILES | Cn1ncc(c1-c1ccc2ccccc2c1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.45,1.7,;-3.12,2.47,;-2.64,3.94,;-1.1,3.94,;-.63,2.47,;-1.87,1.57,;-2.27,.08,;-1.18,-1.01,;-1.58,-2.5,;-3.07,-2.9,;-3.47,-4.38,;-4.95,-4.78,;-6.04,-3.69,;-5.64,-2.21,;-4.16,-1.81,;-3.76,-.32,;-4.85,.77,;-5.94,1.86,;.71,1.7,;.71,.16,;2.04,-.61,;3.38,.16,;3.38,1.7,;2.04,2.47,;4.71,2.47,;4.71,4.01,;3.38,4.78,;6.04,1.7,;6.04,.16,;4.71,-.61,;4.71,-2.15,)| | ||
| Structure | 
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