| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
|---|
| Ligand | BDBM50155231 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_306160 (CHEMBL832348) |
|---|
| IC50 | 7±n/a nM |
|---|
| Citation |  Helal, CJ; Sanner, MA; Cooper, CB; Gant, T; Adam, M; Lucas, JC; Kang, Z; Kupchinsky, S; Ahlijanian, MK; Tate, B; Menniti, FS; Kelly, K; Peterson, M Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Bioorg Med Chem Lett14:5521-5 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 5 |
|---|
| Name: | Cyclin-dependent kinase 5 |
|---|
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33308.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 292 |
|---|
| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
|
|
|
|---|
| BDBM50155231 |
|---|
| n/a |
|---|
| Name | BDBM50155231 |
|---|
| Synonyms: | 2-(1H-Benzoimidazol-5-yl)-N-(5-cyclobutyl-thiazol-2-yl)-acetamide | CHEMBL186898 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N4OS |
|---|
| Mol. Mass. | 312.389 |
|---|
| SMILES | O=C(Cc1ccc2nc[nH]c2c1)Nc1ncc(s1)C1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
