| Reaction Details |
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 | Report a problem with these data |
| Target | Protein cereblon |
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| Ligand | BDBM50586183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2165247 (CHEMBL5050108) |
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| IC50 | 1045±n/a nM |
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| Citation |  Alcock, LJ; Chang, Y; Jarusiewicz, JA; Actis, M; Nithianantham, S; Mayasundari, A; Min, J; Maxwell, D; Hunt, J; Smart, B; Yang, JJ; Nishiguchi, G; Fischer, M; Mullighan, CG; Rankovic, Z Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. ACS Med Chem Lett13:475-482 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein cereblon |
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| Name: | Protein cereblon |
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| Synonyms: | CRBN | CRBN_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50537.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116917 |
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| Residue: | 442 |
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| Sequence: | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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| BDBM50586183 |
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| n/a |
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| Name | BDBM50586183 |
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| Synonyms: | CHEMBL5094176 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H41N11O5S |
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| Mol. Mass. | 775.879 |
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| SMILES | CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NC2CCN(CC2)c2ccc(cc2)C2CCC(=O)NC2=O)nc2[nH]ccc12 |
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| Structure | 
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