| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1D |
|---|
| Ligand | BDBM50156405 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_302836 (CHEMBL827881) |
|---|
| Ki | 2300±n/a nM |
|---|
| Citation |  Zhang, D; Kohlman, D; Krushinski, J; Liang, S; Ying, BP; Reilly, JE; Dinn, SR; Wainscott, DB; Nutter, S; Gough, W; Nelson, DL; Schaus, JM; Xu, YC Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists. Bioorg Med Chem Lett14:6011-6 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1D |
|---|
| Name: | 5-hydroxytryptamine receptor 1D |
|---|
| Synonyms: | 5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 41920.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
|---|
| Residue: | 377 |
|---|
| Sequence: | MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS
|
|
|
|---|
| BDBM50156405 |
|---|
| n/a |
|---|
| Name | BDBM50156405 |
|---|
| Synonyms: | 4-Fluoro-N-[4-(1-methyl-piperidin-4-yl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-benzamide | CHEMBL184994 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24FN3O2 |
|---|
| Mol. Mass. | 369.4326 |
|---|
| SMILES | CN1CCC(CC1)N1CCOc2ccc(NC(=O)c3ccc(F)cc3)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
