| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 4A11 |
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| Ligand | BDBM50591505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2200603 (CHEMBL5113119) |
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| IC50 | 38±n/a nM |
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| Citation |  Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem65:14599-14613 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 4A11 |
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| Name: | Cytochrome P450 4A11 |
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| Synonyms: | 1.14.14.1 | 1.14.14.80 | 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | CP4AB_HUMAN | CYP4A11 | CYP4A2 | CYP4AII | CYPIVA11 | Cytochrome P-450HK-omega | Cytochrome P450 4A11 | Cytochrome P450HL-omega | Fatty acid omega-hydroxylase | Lauric acid omega-hydroxylase | Long-chain fatty acid omega-monooxygenase | Synonyms=CYP4A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59367.30 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119703 |
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| Residue: | 519 |
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| Sequence: | MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF
GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD
SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND
TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS
ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL
LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
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| BDBM50591505 |
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| n/a |
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| Name | BDBM50591505 |
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| Synonyms: | CHEMBL5199278 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N4O3S |
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| Mol. Mass. | 336.409 |
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| SMILES | CS(=O)(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 |r| |
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| Structure | 
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