| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50164693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304677 (CHEMBL827031) |
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| IC50 | >1000±n/a nM |
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| Citation |  Verma, S; Nagarathnam, D; Shao, J; Zhang, L; Zhao, J; Wang, Y; Li, T; Mull, E; Enyedy, I; Wang, C; Zhu, Q; Altieri, M; Jordan, J; Dang, TT; Reddy, S Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett15:1973-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50164693 |
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| n/a |
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| Name | BDBM50164693 |
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| Synonyms: | CHEMBL194721 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(2-chloro-phenyl)-5-trifluoromethyl-pyrimidine-2,4-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClF3N6 |
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| Mol. Mass. | 404.776 |
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| SMILES | FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1ccccc1Cl |
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| Structure | 
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