Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50166456 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303284 (CHEMBL828277) |
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Ki | 7.8±n/a nM |
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Citation | Guo, Z; Chen, Y; Huang, CQ; Gross, TD; Pontillo, J; Rowbottom, MW; Saunders, J; Struthers, S; Tucci, FC; Xie, Q; Wade, W; Zhu, YF; Wu, D; Chen, C Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers. Bioorg Med Chem Lett15:2519-22 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50166456 |
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n/a |
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Name | BDBM50166456 |
Synonyms: | (R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-phenylpyrimidine-2,4(1H,3H)-dione | 3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-5-phenyl-1H-pyrimidine-2,4-dione | CHEMBL365985 |
Type | Small organic molecule |
Emp. Form. | C26H21F4N3O2 |
Mol. Mass. | 483.4575 |
SMILES | N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1)c1ccccc1 |r| |
Structure |
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