| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase |
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| Ligand | BDBM50168181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305951 (CHEMBL831965) |
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| IC50 | 7.4±n/a nM |
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| Citation |  Biftu, T; Feng, D; Ponpipom, M; Girotra, N; Liang, GB; Qian, X; Bugianesi, R; Simeone, J; Chang, L; Gurnett, A; Liberator, P; Dulski, P; Leavitt, PS; Crumley, T; Misura, A; Murphy, T; Rattray, S; Samaras, S; Tamas, T; Mathew, J; Brown, C; Thompson, D; Schmatz, D; Fisher, M; Wyvratt, M Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. Bioorg Med Chem Lett15:3296-301 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase |
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| Name: | cGMP-dependent protein kinase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 112911.27 |
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| Organism: | Eimeria tenella |
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| Description: | ChEMBL_469577 |
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| Residue: | 1003 |
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| Sequence: | MGACSSKAQHQTRDPEPREQQAAQEQKSTGPSGAPNDAPAPAEAERKMSGSSATAPKGEM
PTASTGTPEQQQQQQQQQQQQQEQQQHPEHQQSEKQQQHGEEQQQERKPSQQQQNEEAAA
PHKHGGERKVQKAIKQQEDTQAEDARLLGHLEKREKTPSDLSLIRDSLSTNLVCSSLNDA
EVEALANAVEFFTFKKGDVVTKQGESGSYFFIVHSGEFEVIVNDKVVNKILTGQAFGEIS
LIHNSARTATIKTLSEDAALWGVQRQVFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQ
KNVITNALVVQSFQPGQAIVKEGEKGDVLYILKSGKALVSIKNKEVRVLQRGEYFGERAL
LYDEPRSATITAEEPTVCVSIGRDLLDRVLGNLQHVLFRNIMLEALQQSKVFASFPTEQL
SRLIGSVVVKDYPENYIILDRENRTRASASALFSAQGVRFFFVLEGEVSVFAYKDKSSSS
SSSSSSSSSSSSAEGEMELHLIDTLKRGQAFGDEYVLSPNKPFAHCVKSNGPTKLALLTA
SALTATLGGQDIDETLDYNNKLAITKKMYIFRYLSEQQTQTLIKAFKTVRYTQGESIIRE
GEIGSRFFIIKLGEVVILKGEKRVRTLGRHDYFGERALLHDERRSATVAANSPEVDLWVV
DKDVFLQIVKGPMLTHLEERIRMQDTKVEFKDLNVVRVVGRGTFGTVKLVQHIPTQMRYA
LKCVSRKSVVALNQQDHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYD
AIRKLGLLGRYQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKK
MQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFR
DILAGKLIFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFSDFDWDRLAG
RDLSPPLLPKGEIYAEDAEEGGLDIEEDEGIELEDEYEWDKDF
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| BDBM50168181 |
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| n/a |
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| Name | BDBM50168181 |
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| Synonyms: | 4-[2-(3-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)-1H-pyrrol-3-yl]-pyridine | CHEMBL372057 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22FN3 |
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| Mol. Mass. | 335.4179 |
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| SMILES | CN1CCC(CC1)c1cc(c([nH]1)-c1cccc(F)c1)-c1ccncc1 |
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| Structure | 
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