Found 215 hits with Last Name = 'dulski' and Initial = 'p' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone deacetylase
(Cryptosporidium parvum) | BDBM50238632
((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O |r| Show InChI InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366737
(CHEMBL1793971)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cnc2ccccc2c1O Show InChI InChI=1S/C33H45N5O6/c1-4-20(3)27-33(44)38-18-12-11-17-26(38)31(42)35-25(16-8-6-7-13-21(39)5-2)30(41)37-28(32(43)36-27)23-19-34-24-15-10-9-14-22(24)29(23)40/h9-10,14-15,19-20,25-28H,4-8,11-13,16-18H2,1-3H3,(H,34,40)(H,35,42)(H,36,43)(H,37,41)/t20-,25-,26+,27-,28-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366726
(CHEMBL1793982)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cnc2ccccc2c1N1CCCCC1 Show InChI InChI=1S/C38H54N6O5/c1-4-25(3)32-38(49)44-23-15-12-20-31(44)36(47)40-30(19-9-6-8-16-26(45)5-2)35(46)42-33(37(48)41-32)28-24-39-29-18-11-10-17-27(29)34(28)43-21-13-7-14-22-43/h10-11,17-18,24-25,30-33H,4-9,12-16,19-23H2,1-3H3,(H,40,47)(H,41,48)(H,42,46)/t25-,30-,31+,32-,33+/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366733
(CHEMBL1793973)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cn(OC)c2ccccc2c1=O Show InChI InChI=1S/C34H47N5O7/c1-5-21(3)28-34(45)38-19-13-12-18-27(38)32(43)35-25(16-9-7-8-14-22(40)6-2)31(42)37-29(33(44)36-28)24-20-39(46-4)26-17-11-10-15-23(26)30(24)41/h10-11,15,17,20-21,25,27-29H,5-9,12-14,16,18-19H2,1-4H3,(H,35,43)(H,36,44)(H,37,42)/t21-,25-,27+,28-,29-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366749
(CHEMBL1793983)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cnc2ccccc2c1Cl Show InChI InChI=1S/C33H44ClN5O5/c1-4-20(3)28-33(44)39-18-12-11-17-26(39)31(42)36-25(16-8-6-7-13-21(40)5-2)30(41)38-29(32(43)37-28)23-19-35-24-15-10-9-14-22(24)27(23)34/h9-10,14-15,19-20,25-26,28-29H,4-8,11-13,16-18H2,1-3H3,(H,36,42)(H,37,43)(H,38,41)/t20-,25-,26+,28-,29+/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366736
(CHEMBL1793972)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cn(CC)c2ccccc2c1=O Show InChI InChI=1S/C35H49N5O6/c1-5-22(4)29-35(46)40-20-14-13-19-28(40)33(44)36-26(17-10-8-9-15-23(41)6-2)32(43)38-30(34(45)37-29)25-21-39(7-3)27-18-12-11-16-24(27)31(25)42/h11-12,16,18,21-22,26,28-30H,5-10,13-15,17,19-20H2,1-4H3,(H,36,44)(H,37,45)(H,38,43)/t22-,26-,28+,29-,30-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366727
(CHEMBL1793981)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)C(C)(C)C)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O Show InChI InChI=1S/C30H50N4O6/c1-7-19(3)25-29(40)34-17-13-12-16-23(34)28(39)31-21(15-11-9-10-14-20(35)8-2)26(37)32-22(27(38)33-25)18-24(36)30(4,5)6/h19,21-23,25H,7-18H2,1-6H3,(H,31,39)(H,32,37)(H,33,38)/t19-,21-,22-,23+,25-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366729
(CHEMBL1793969)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C32H46N4O6/c1-4-21(3)27-32(42)36-19-13-12-18-25(36)30(40)33-24(17-11-7-10-16-23(37)5-2)29(39)35-28(31(41)34-27)26(38)20-22-14-8-6-9-15-22/h6,8-9,14-15,21,24-25,27-28H,4-5,7,10-13,16-20H2,1-3H3,(H,33,40)(H,34,41)(H,35,39)/t21-,24-,25+,27-,28+/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366752
(CHEMBL1793970)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O)c1cnc2ccccc2c1O Show InChI InChI=1S/C33H45N5O6/c1-4-20(3)27-33(44)38-18-12-11-17-26(38)31(42)35-25(16-8-6-7-13-21(39)5-2)30(41)37-28(32(43)36-27)23-19-34-24-15-10-9-14-22(24)29(23)40/h9-10,14-15,19-20,25-28H,4-8,11-13,16-18H2,1-3H3,(H,34,40)(H,35,42)(H,36,43)(H,37,41)/t20-,25-,26+,27-,28+/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366728
(CHEMBL1793978)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)Cc2ccccc2)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O Show InChI InChI=1S/C33H48N4O6/c1-4-22(3)29-33(43)37-19-13-12-18-28(37)32(42)34-26(17-11-7-10-16-24(38)5-2)30(40)35-27(31(41)36-29)21-25(39)20-23-14-8-6-9-15-23/h6,8-9,14-15,22,26-29H,4-5,7,10-13,16-21H2,1-3H3,(H,34,42)(H,35,40)(H,36,41)/t22-,26-,27-,28+,29-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366750
(CHEMBL1793987)Show SMILES CCCCCCCCCCC(=O)C[C@@H]1NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C(=O)[C@@H](NC1=O)[C@@H](C)CC Show InChI InChI=1S/C36H62N4O6/c1-5-8-9-10-11-12-13-15-21-28(42)25-30-34(44)39-32(26(4)6-2)36(46)40-24-19-18-23-31(40)35(45)37-29(33(43)38-30)22-17-14-16-20-27(41)7-3/h26,29-32H,5-25H2,1-4H3,(H,37,45)(H,38,43)(H,39,44)/t26-,29-,30-,31+,32-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168170
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES NCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H27FN4/c24-20-4-2-19(3-5-20)23-21(17-6-11-26-12-7-17)16-22(27-23)18-8-14-28(15-9-18)13-1-10-25/h2-7,11-12,16,18,27H,1,8-10,13-15,25H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374578
(CHEMBL401749)Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CC2CNCCN2)CC1 |w:23.25| Show InChI InChI=1S/C25H30FN5/c26-21-3-1-20(2-4-21)25-23(18-5-9-27-10-6-18)15-24(30-25)19-7-13-31(14-8-19)17-22-16-28-11-12-29-22/h1-6,9-10,15,19,22,28-30H,7-8,11-14,16-17H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374594
(CHEMBL444009)Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CCN2CCC2)CC1 Show InChI InChI=1S/C25H29FN4/c26-22-4-2-21(3-5-22)25-23(19-6-10-27-11-7-19)18-24(28-25)20-8-14-30(15-9-20)17-16-29-12-1-13-29/h2-7,10-11,18,20,28H,1,8-9,12-17H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50366693
(CHEMBL1793812)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)C2CO2)NC(=O)[C@H]2CCCCN2CC1=O Show InChI InChI=1S/C35H49N5O7/c1-4-22(2)32-30(42)20-39-17-11-10-15-28(39)35(45)36-25(13-6-5-7-16-29(41)31-21-47-31)33(43)37-26(34(44)38-32)18-23-19-40(46-3)27-14-9-8-12-24(23)27/h8-9,12,14,19,22,25-26,28,31-32H,4-7,10-11,13,15-18,20-21H2,1-3H3,(H,36,45)(H,37,43)(H,38,44)/t22-,25-,26-,28+,31?,32-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells |
Bioorg Med Chem Lett 11: 107-11 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XNX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168185
(4-[2-(3-Bromo-4-fluoro-phenyl)-5-(1-methyl-piperid...)Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)c(Br)c1)-c1ccncc1 Show InChI InChI=1S/C21H21BrFN3/c1-26-10-6-15(7-11-26)20-13-17(14-4-8-24-9-5-14)21(25-20)16-2-3-19(23)18(22)12-16/h2-5,8-9,12-13,15,25H,6-7,10-11H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171694
((R)-5-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-py...)Show SMILES O[C@H]1CNC(CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)C1 Show InChI InChI=1S/C25H29FN4O/c26-20-3-1-19(2-4-20)25-23(17-5-9-27-10-6-17)14-24(29-25)18-7-11-30(12-8-18)16-21-13-22(31)15-28-21/h1-6,9-10,14,18,21-22,28-29,31H,7-8,11-13,15-16H2/t21?,22-/m1/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374591
(CHEMBL255128)Show SMILES O[C@H]1CN[C@H](CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)C1 Show InChI InChI=1S/C25H29FN4O/c26-20-3-1-19(2-4-20)25-23(17-5-9-27-10-6-17)14-24(29-25)18-7-11-30(12-8-18)16-21-13-22(31)15-28-21/h1-6,9-10,14,18,21-22,28-29,31H,7-8,11-13,15-16H2/t21-,22+/m0/s1 | UniProtKB/TrEMBL
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374587
(CHEMBL272573)Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CC2CNCCO2)CC1 |w:23.25| Show InChI InChI=1S/C25H29FN4O/c26-21-3-1-20(2-4-21)25-23(18-5-9-27-10-6-18)15-24(29-25)19-7-12-30(13-8-19)17-22-16-28-11-14-31-22/h1-6,9-10,15,19,22,28-29H,7-8,11-14,16-17H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50218940
(CHEMBL1793991)Show SMILES [H][C@](C)(CC)[C@]1([H])NC(=O)[C@]([H])(Cc2cn(CN3CCCC3)c3ccccc23)NC(=O)[C@]([H])(CCCCCC(=O)CC)NC(=O)[C@@]2([H])CCCCN2C1=O Show InChI InChI=1S/C38H56N6O5/c1-4-26(3)34-38(49)44-22-12-11-19-33(44)37(48)39-30(17-8-6-7-15-28(45)5-2)35(46)40-31(36(47)41-34)23-27-24-43(25-42-20-13-14-21-42)32-18-10-9-16-29(27)32/h9-10,16,18,24,26,30-31,33-34H,4-8,11-15,17,19-23,25H2,1-3H3,(H,39,48)(H,40,46)(H,41,47)/t26-,30-,31-,33+,34-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan... |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Cryptosporidium parvum) | BDBM50366738
(CHEMBL1793985)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c([nH]c3ccccc23)-c2cc(OC)cc(OC)c2)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O Show InChI InChI=1S/C41H55N5O7/c1-6-25(3)36-41(51)46-20-14-13-19-35(46)40(50)43-33(18-10-8-9-15-27(47)7-2)38(48)44-34(39(49)45-36)24-31-30-16-11-12-17-32(30)42-37(31)26-21-28(52-4)23-29(22-26)53-5/h11-12,16-17,21-23,25,33-36,42H,6-10,13-15,18-20,24H2,1-5H3,(H,43,50)(H,44,48)(H,45,49)/t25-,33-,34-,35+,36-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase enzyme derived from partially purified extracts of Eimeria tenella protozoa using [3H]11 as radioliga... |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50366738
(CHEMBL1793985)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c([nH]c3ccccc23)-c2cc(OC)cc(OC)c2)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O Show InChI InChI=1S/C41H55N5O7/c1-6-25(3)36-41(51)46-20-14-13-19-35(46)40(50)43-33(18-10-8-9-15-27(47)7-2)38(48)44-34(39(49)45-36)24-31-30-16-11-12-17-32(30)42-37(31)26-21-28(52-4)23-29(22-26)53-5/h11-12,16-17,21-23,25,33-36,42H,6-10,13-15,18-20,24H2,1-5H3,(H,43,50)(H,44,48)(H,45,49)/t25-,33-,34-,35+,36-/m0/s1 | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan... |
Bioorg Med Chem Lett 11: 113-7 (2001)
BindingDB Entry DOI: 10.7270/Q2M045ZB |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50366696
(CHEMBL1793811)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)NO)NC(=O)[C@H]2CCCCN2CC1=O Show InChI InChI=1S/C33H48N6O7/c1-4-21(2)30-28(40)20-38-17-11-10-15-27(38)33(44)34-24(13-6-5-7-16-29(41)37-45)31(42)35-25(32(43)36-30)18-22-19-39(46-3)26-14-9-8-12-23(22)26/h8-9,12,14,19,21,24-25,27,30,45H,4-7,10-11,13,15-18,20H2,1-3H3,(H,34,44)(H,35,42)(H,36,43)(H,37,41)/t21-,24-,25-,27+,30-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells |
Bioorg Med Chem Lett 11: 107-11 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XNX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168208
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES NC1(CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)CC1 Show InChI InChI=1S/C24H27FN4/c25-20-3-1-19(2-4-20)23-21(17-5-11-27-12-6-17)15-22(28-23)18-7-13-29(14-8-18)16-24(26)9-10-24/h1-6,11-12,15,18,28H,7-10,13-14,16,26H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374588
(CHEMBL255381)Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CC1)C(=O)C1CNCCO1 |w:26.29| Show InChI InChI=1S/C25H27FN4O2/c26-20-3-1-19(2-4-20)24-21(17-5-9-27-10-6-17)15-22(29-24)18-7-12-30(13-8-18)25(31)23-16-28-11-14-32-23/h1-6,9-10,15,18,23,28-29H,7-8,11-14,16H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168187
(4-{2-(4-Fluoro-phenyl)-5-[1-(1-methyl-azetidin-2-y...)Show SMILES CN1CCC1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C25H29FN4/c1-29-13-10-22(29)17-30-14-8-19(9-15-30)24-16-23(18-6-11-27-12-7-18)25(28-24)20-2-4-21(26)5-3-20/h2-7,11-12,16,19,22,28H,8-10,13-15,17H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168202
(2-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES NCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C22H25FN4/c23-19-3-1-18(2-4-19)22-20(16-5-10-25-11-6-16)15-21(26-22)17-7-12-27(13-8-17)14-9-24/h1-6,10-11,15,17,26H,7-9,12-14,24H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374592
(CHEMBL271922)Show SMILES CN1CC[C@H]1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C25H29FN4/c1-29-13-10-22(29)17-30-14-8-19(9-15-30)24-16-23(18-6-11-27-12-7-18)25(28-24)20-2-4-21(26)5-3-20/h2-7,11-12,16,19,22,28H,8-10,13-15,17H2,1H3/t22-/m0/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168206
(4-[5-(1-Ethyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-...)Show SMILES CCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C22H24FN3/c1-2-26-13-9-17(10-14-26)21-15-20(16-7-11-24-12-8-16)22(25-21)18-3-5-19(23)6-4-18/h3-8,11-12,15,17,25H,2,9-10,13-14H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50366712
(CHEMBL1793822)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)C(C)O)NC(=O)[C@H]2CCCCN2CC1=O Show InChI InChI=1S/C35H51N5O7/c1-5-22(2)32-31(43)21-39-18-12-11-16-29(39)35(46)36-26(14-7-6-8-17-30(42)23(3)41)33(44)37-27(34(45)38-32)19-24-20-40(47-4)28-15-10-9-13-25(24)28/h9-10,13,15,20,22-23,26-27,29,32,41H,5-8,11-12,14,16-19,21H2,1-4H3,(H,36,46)(H,37,44)(H,38,45)/t22-,23?,26-,27-,29+,32-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells |
Bioorg Med Chem Lett 11: 107-11 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XNX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168192
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES CC(=O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H24FN3O/c1-16(28)15-27-12-8-18(9-13-27)22-14-21(17-6-10-25-11-7-17)23(26-22)19-2-4-20(24)5-3-19/h2-7,10-11,14,18,26H,8-9,12-13,15H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374580
(CHEMBL271638)Show SMILES CN1C[C@H](O)C[C@H]1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C26H31FN4O/c1-30-17-23(32)14-22(30)16-31-12-8-19(9-13-31)25-15-24(18-6-10-28-11-7-18)26(29-25)20-2-4-21(27)5-3-20/h2-7,10-11,15,19,22-23,29,32H,8-9,12-14,16-17H2,1H3/t22-,23+/m0/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50183915
((5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-y...)Show InChI InChI=1S/C18H18FN3/c1-22(2)12-16-11-17(13-7-9-20-10-8-13)18(21-16)14-3-5-15(19)6-4-14/h3-11,21H,12H2,1-2H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella PKG |
Bioorg Med Chem Lett 16: 2817-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.041
BindingDB Entry DOI: 10.7270/Q21V5DK1 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374590
(CHEMBL406910)Show SMILES CCN1C[C@H](O)C[C@H]1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C27H33FN4O/c1-2-32-18-24(33)15-23(32)17-31-13-9-20(10-14-31)26-16-25(19-7-11-29-12-8-19)27(30-26)21-3-5-22(28)6-4-21/h3-8,11-12,16,20,23-24,30,33H,2,9-10,13-15,17-18H2,1H3/t23-,24+/m0/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171685
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES CCCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C25H30FN3O/c1-2-3-22(30)17-29-14-10-19(11-15-29)24-16-23(18-8-12-27-13-9-18)25(28-24)20-4-6-21(26)7-5-20/h4-9,12-13,16,19,22,28,30H,2-3,10-11,14-15,17H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374593
(CHEMBL429745)Show SMILES CC(CN1CCC1)N1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 |w:1.0| Show InChI InChI=1S/C26H31FN4/c1-19(18-30-13-2-14-30)31-15-9-21(10-16-31)25-17-24(20-7-11-28-12-8-20)26(29-25)22-3-5-23(27)6-4-22/h3-8,11-12,17,19,21,29H,2,9-10,13-16,18H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171698
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES CC(O)C(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C24H28FN3O2/c1-16(29)23(30)15-28-12-8-18(9-13-28)22-14-21(17-6-10-26-11-7-17)24(27-22)19-2-4-20(25)5-3-19/h2-7,10-11,14,16,18,23,27,29-30H,8-9,12-13,15H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50366713
(CHEMBL1793816)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)OC)NC(=O)[C@H]2CCCCN2CC1=O Show InChI InChI=1S/C34H49N5O7/c1-5-22(2)31-29(40)21-38-18-12-11-16-28(38)34(44)35-25(14-7-6-8-17-30(41)45-3)32(42)36-26(33(43)37-31)19-23-20-39(46-4)27-15-10-9-13-24(23)27/h9-10,13,15,20,22,25-26,28,31H,5-8,11-12,14,16-19,21H2,1-4H3,(H,35,44)(H,36,42)(H,37,43)/t22-,25-,26-,28+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells |
Bioorg Med Chem Lett 11: 107-11 (2001)
BindingDB Entry DOI: 10.7270/Q2QR4XNX |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171707
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES CCCCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C26H32FN3O/c1-2-3-4-23(31)18-30-15-11-20(12-16-30)25-17-24(19-9-13-28-14-10-19)26(29-25)21-5-7-22(27)8-6-21/h5-10,13-14,17,20,23,29,31H,2-4,11-12,15-16,18H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168190
(4-[2-(3-Chloro-4-fluoro-phenyl)-5-(1-methyl-piperi...)Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)c(Cl)c1)-c1ccncc1 Show InChI InChI=1S/C21H21ClFN3/c1-26-10-6-15(7-11-26)20-13-17(14-4-8-24-9-5-14)21(25-20)16-2-3-19(23)18(22)12-16/h2-5,8-9,12-13,15,25H,6-7,10-11H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171705
(1-Benzyloxy-3-{4-[5-(4-fluoro-phenyl)-4-pyridin-4-...)Show SMILES OC(COCc1ccccc1)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C30H32FN3O2/c31-26-8-6-25(7-9-26)30-28(23-10-14-32-15-11-23)18-29(33-30)24-12-16-34(17-13-24)19-27(35)21-36-20-22-4-2-1-3-5-22/h1-11,14-15,18,24,27,33,35H,12-13,16-17,19-21H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171699
((S)-1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-py...)Show SMILES C[C@H](O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H26FN3O/c1-16(28)15-27-12-8-18(9-13-27)22-14-21(17-6-10-25-11-7-17)23(26-22)19-2-4-20(24)5-3-19/h2-7,10-11,14,16,18,26,28H,8-9,12-13,15H2,1H3/t16-/m0/s1 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171693
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES OCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-3-1-18(2-4-19)23-21(16-5-9-25-10-6-16)13-22(26-23)17-7-11-27(12-8-17)14-20(29)15-28/h1-6,9-10,13,17,20,26,28-29H,7-8,11-12,14-15H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171693
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES OCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-3-1-18(2-4-19)23-21(16-5-9-25-10-6-16)13-22(26-23)17-7-11-27(12-8-17)14-20(29)15-28/h1-6,9-10,13,17,20,26,28-29H,7-8,11-12,14-15H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168176
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES OCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H26FN3O/c24-20-4-2-19(3-5-20)23-21(17-6-10-25-11-7-17)16-22(26-23)18-8-13-27(14-9-18)12-1-15-28/h2-7,10-11,16,18,26,28H,1,8-9,12-15H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 15: 3296-301 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50168176
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES OCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C23H26FN3O/c24-20-4-2-19(3-5-20)23-21(17-6-10-25-11-7-17)16-22(26-23)18-8-13-27(14-9-18)12-1-15-28/h2-7,10-11,16,18,26,28H,1,8-9,12-15H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171695
((R)1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyr...)Show SMILES COCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C24H28FN3O2/c1-30-16-21(29)15-28-12-8-18(9-13-28)23-14-22(17-6-10-26-11-7-17)24(27-23)19-2-4-20(25)5-3-19/h2-7,10-11,14,18,21,27,29H,8-9,12-13,15-16H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171688
(1-Ethoxy-3-{4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-...)Show SMILES CCOCC(O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C25H30FN3O2/c1-2-31-17-22(30)16-29-13-9-19(10-14-29)24-15-23(18-7-11-27-12-8-18)25(28-24)20-3-5-21(26)6-4-20/h3-8,11-12,15,19,22,28,30H,2,9-10,13-14,16-17H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50171702
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)Show SMILES OC(COc1ccccc1)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C29H30FN3O2/c30-24-8-6-23(7-9-24)29-27(21-10-14-31-15-11-21)18-28(32-29)22-12-16-33(17-13-22)19-25(34)20-35-26-4-2-1-3-5-26/h1-11,14-15,18,22,25,32,34H,12-13,16-17,19-20H2 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against cGMP-dependent protein kinase from Eimeria tenella |
Bioorg Med Chem Lett 15: 4570-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.096
BindingDB Entry DOI: 10.7270/Q2416WM9 |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50374585
(CHEMBL255631)Show SMILES CN1CCOC(CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)C1 |w:5.5| Show InChI InChI=1S/C26H31FN4O/c1-30-14-15-32-23(17-30)18-31-12-8-20(9-13-31)25-16-24(19-6-10-28-11-7-19)26(29-25)21-2-4-22(27)5-3-21/h2-7,10-11,16,20,23,29H,8-9,12-15,17-18H2,1H3 | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase |
Bioorg Med Chem Lett 18: 2019-22 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.104
BindingDB Entry DOI: 10.7270/Q2BV7HHX |
More data for this
Ligand-Target Pair | |
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