| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase G2 |
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| Ligand | BDBM50171504 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302801 (CHEMBL876359) |
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| Ki | 127000±n/a nM |
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| Citation |  Davies, LC; Friedlos, F; Hedley, D; Martin, J; Ogilvie, LM; Scanlon, IJ; Springer, CJ Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy. J Med Chem48:5321-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase G2 |
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| Name: | Carboxypeptidase G2 |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44005.37 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_302801 |
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| Residue: | 412 |
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| Sequence: | MHARRLPRLLPLALAFLLSPAAFAADTPAAELLRQAEAERPAYLDTLRQLVAVDSGTGQA
EGLGQLSALLAERLQALGAQVRSAPATPSAGDNLVATLDGTGSKRFLLMIHYDTVFAAGS
AAKRPFREDAERAYGPGVADAKGGVAMVLHALALLRQQGFRDYGRITVLFNPDEETGSAG
SKQLIAELARQQDYVFSYEPPDRDAVTVATNGIDGLLLEVKGRSSHAGSAPEQGRNAILE
LSHQLLRLKDLGDPAKGTTLNWTLARGGEKRNIIPAEASAEADMRYSDPAESERVLADAR
KLTGERLVADTEVSLRLDKGRPPLVKNPASQRLAETAQTLYGRIGKRIEPIAMRFGTDAG
YAYVPGSDKPAVLETLGVVGAGLHSEAEYLELSSIAPRLYLTVALIRELSAD
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| BDBM50171504 |
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| n/a |
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| Name | BDBM50171504 |
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| Synonyms: | (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoylamino}-pentanedioic acid | CHEMBL362970 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16Cl2F4N2O5 |
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| Mol. Mass. | 463.208 |
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| SMILES | OC(=O)CC[C@H](NC(=O)c1c(F)c(F)c(N(CCCl)CCCl)c(F)c1F)C(O)=O |
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| Structure | 
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