Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50173811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321537 (CHEMBL880597) |
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IC50 | 8200±n/a nM |
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Citation | Deng, BL; Hartman, TL; Buckheit, RW; Pannecouque, C; De Clercq, E; Fanwick, PE; Cushman, M Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem48:6140-55 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50173811 |
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n/a |
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Name | BDBM50173811 |
Synonyms: | (Z)-6-(5-Chloro-2-methoxy-phenyl)-6-(2,7-dimethyl-3-oxo-2,3-dihydro-benzo[d]isoxazol-5-yl)-hex-5-enoic acid methyl ester | CHEMBL196274 |
Type | Small organic molecule |
Emp. Form. | C23H24ClNO5 |
Mol. Mass. | 429.893 |
SMILES | COC(=O)CCC\C=C(\c1cc(C)c2on(C)c(=O)c2c1)c1cc(Cl)ccc1OC |
Structure |
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