| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50175099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326962 (CHEMBL853297) |
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| IC50 | 57±n/a nM |
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| Citation |  Shi, Y; Zhang, J; Stein, PD; Shi, M; O'Connor, SP; Bisaha, SN; Li, C; Atwal, KS; Bisacchi, GS; Sitkoff, D; Pudzianowski, AT; Liu, EC; Hartl, KS; Seiler, SM; Youssef, S; Steinbacher, TE; Schumacher, WA; Rendina, AR; Bozarth, JM; Peterson, TL; Zhang, G; Zahler, R Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors. Bioorg Med Chem Lett15:5453-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50175099 |
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| n/a |
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| Name | BDBM50175099 |
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| Synonyms: | (S,Z)-3-(2-methylbenzofuran-5-ylamino)-2-(4-methylpiperidine-1-carbonyl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-ylamino)acrylonitrile | CHEMBL200961 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40N6O4 |
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| Mol. Mass. | 560.6871 |
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| SMILES | CC1CCN(CC1)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 |w:30.33| |
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| Structure | 
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