| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM13465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321363 (CHEMBL881507) |
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| IC50 | 190±n/a nM |
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| Citation |  Combs, AP; Yue, EW; Bower, M; Ala, PJ; Wayland, B; Douty, B; Takvorian, A; Polam, P; Wasserman, Z; Zhu, W; Crawley, ML; Pruitt, J; Sparks, R; Glass, B; Modi, D; McLaughlin, E; Bostrom, L; Li, M; Galya, L; Blom, K; Hillman, M; Gonneville, L; Reid, BG; Wei, M; Becker-Pasha, M; Klabe, R; Huber, R; Li, Y; Hollis, G; Burn, TC; Wynn, R; Liu, P; Metcalf, B Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics. J Med Chem48:6544-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM13465 |
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| n/a |
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| Name | BDBM13465 |
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| Synonyms: | (2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl}ethyl]-2-acetamido-3-phenylpropanamide | CHEMBL382311 | IZD 8 | Isothiazolidinone (IZD) deriv. 6 | Saturated (S)-IZD |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N4O6S |
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| Mol. Mass. | 486.541 |
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| SMILES | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)[C@@H]1CC(=O)NS1(=O)=O)C(N)=O |r| |
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| Structure | 
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