| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
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| Ligand | BDBM50178832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2231146 (CHEMBL5144918) |
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| IC50 | 1000±n/a nM |
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| Citation |  Andrews, DM; Cartic, S; Cosulich, S; Divecha, N; Faulder, P; Flemington, V; Kern, O; Kettle, JG; MacDonald, E; McKelvie, J; Pike, KG; Roberts, B; Rowlinson, R; Smith, JM; Stockley, M; Swarbrick, ME; Treinies, I; Waring, MJ Identification and optimization of a novel series of selective PIP5K inhibitors. Bioorg Med Chem54:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
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| Name: | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
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| Synonyms: | 2.7.1.68 | PI51B_HUMAN | PIP5K1-beta | PIP5K1B | PIP5KIbeta | Phosphatidylinositol 4-phosphate 5-kinase type I beta | Protein STM-7 | PtdIns(4)P-5-kinase 1 beta | STM7 | Synonyms=STM7 | Type I phosphatidylinositol 4-phosphate 5-kinase beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61038.12 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120312 |
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| Residue: | 540 |
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| Sequence: | MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVV
ESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNP
GASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGG
INIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYF
DTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQ
KVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKK
LEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKAT
SQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTIS
SSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL
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| BDBM50178832 |
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| n/a |
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| Name | BDBM50178832 |
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| Synonyms: | CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-2-yl)tetrahydrofuran-3-carboxamide | N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N4O2 |
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| Mol. Mass. | 360.4091 |
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| SMILES | O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1 |
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| Structure | 
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