| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50136730 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330030 (CHEMBL853015) |
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| IC50 | 160000±n/a nM |
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| Citation |  McKew, JC; Foley, MA; Thakker, P; Behnke, ML; Lovering, FE; Sum, FW; Tam, S; Wu, K; Shen, MW; Zhang, W; Gonzalez, M; Liu, S; Mahadevan, A; Sard, H; Khor, SP; Clark, JD Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization. J Med Chem49:135-58 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50136730 |
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| n/a |
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| Name | BDBM50136730 |
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| Synonyms: | 4-((1-benzhydryl-6-chloro-1H-indol-3-yl)methyl)-3-methoxybenzoic acid | 4-(1-Benzhydryl-6-chloro-1H-indol-3-ylmethyl)-3-methoxy-benzoic acid | CHEMBL139858 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24ClNO3 |
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| Mol. Mass. | 481.969 |
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| SMILES | COc1cc(ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2cc(Cl)ccc12)C(O)=O |
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| Structure | 
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