Reaction Details |
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Target | Cytosolic phospholipase A2 |
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Ligand | BDBM50180068 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_330030 (CHEMBL853015) |
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IC50 | 3000±n/a nM |
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Citation | McKew, JC; Foley, MA; Thakker, P; Behnke, ML; Lovering, FE; Sum, FW; Tam, S; Wu, K; Shen, MW; Zhang, W; Gonzalez, M; Liu, S; Mahadevan, A; Sard, H; Khor, SP; Clark, JD Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization. J Med Chem49:135-58 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytosolic phospholipase A2 |
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Name: | Cytosolic phospholipase A2 |
Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
Type: | Protein |
Mol. Mass.: | 85219.30 |
Organism: | Homo sapiens (Human) |
Description: | P47712 |
Residue: | 749 |
Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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BDBM50180068 |
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n/a |
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Name | BDBM50180068 |
Synonyms: | 3-[4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]-ethoxy]phenyl]propanoic acid | CHEMBL382306 |
Type | Small organic molecule |
Emp. Form. | C33H30ClNO3 |
Mol. Mass. | 524.049 |
SMILES | Cc1c(CCOc2ccc(CCC(O)=O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1 |
Structure |
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