| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 3 |
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| Ligand | BDBM426610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2235955 (CHEMBL5149727) |
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| IC50 | 25±n/a nM |
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| Citation |  Jacobs, JW; Leadbetter, MR; Bell, N; Koo-McCoy, S; Carreras, CW; He, L; Kohler, J; Kozuka, K; Labonté, ED; Navre, M; Spencer, AG; Charmot, D Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na ACS Med Chem Lett13:1043-1051 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 3 |
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| Name: | Sodium/hydrogen exchanger 3 |
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| Synonyms: | NHE-3 | Na(+)/H(+) exchanger 3 | Nhe3 | SL9A3_RAT | Slc9a3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93115.43 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_116967 |
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| Residue: | 831 |
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| Sequence: | MWHPALGPGWKPLLALAVAVTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWIL
VASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPI
VLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLL
FGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVT
GVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEM
LSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVI
WTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALV
VLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRA
FDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDA
ISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLE
QRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLE
SFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEE
ATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVP
SQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM
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| BDBM426610 |
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| n/a |
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| Name | BDBM426610 |
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| Synonyms: | N1,N4-bis(2-(2-(2-(2-(3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethoxy)ethyl)terephthalamide | US10543207, Example 216 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H68Cl4N6O12S2 |
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| Mol. Mass. | 1223.114 |
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| SMILES | CN1CC(c2cccc(c2)S(=O)(=O)NCCOCCOCCOCCNC(=O)c2ccc(cc2)C(=O)NCCOCCOCCOCCNS(=O)(=O)c2cccc(c2)C2CN(C)Cc3c(Cl)cc(Cl)cc23)c2cc(Cl)cc(Cl)c2C1 |
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| Structure | 
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