Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50181201 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_345662 (CHEMBL870659) |
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IC50 | 2.8±n/a nM |
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Citation | Liu, B; Liu, M; Xin, Z; Zhao, H; Serby, MD; Kosogof, C; Nelson, LT; Szczepankiewicz, BG; Kaszubska, W; Schaefer, VG; Falls, HD; Lin, CW; Collins, CA; Sham, HL; Liu, G Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration. Bioorg Med Chem Lett16:1864-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50181201 |
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n/a |
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Name | BDBM50181201 |
Synonyms: | 5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(isopentyloxymethyl)pyrimidine-2,4-diamine | CHEMBL205445 |
Type | Small organic molecule |
Emp. Form. | C24H31N5O3S |
Mol. Mass. | 469.6 |
SMILES | CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1 |
Structure |
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