| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Ligand | BDBM7392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2237712 (CHEMBL5151608) |
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| IC50 | 1000±n/a nM |
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| Citation |  Wang, H; Wang, Z; Wei, C; Wang, J; Xu, Y; Bai, G; Yao, Q; Zhang, L; Chen, Y Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship. Eur J Med Chem223:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Synonyms: | Glycogen synthase kinase-3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2105817 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46774.42 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_939732 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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| Component 2 |
| Name: | [Tau protein] kinase |
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| Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51010.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_117799 |
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| Residue: | 483 |
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| Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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| BDBM7392 |
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| n/a |
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| Name | BDBM7392 |
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| Synonyms: | 2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one | Indirubin | Indirubin derivative, 1 | cid_5318433 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10N2O2 |
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| Mol. Mass. | 262.2628 |
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| SMILES | O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O |
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| Structure | 
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