| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM388323 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2237803 (CHEMBL5151699) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Klein, M; Busch, M; Friese-Hamim, M; Crosignani, S; Fuchss, T; Musil, D; Rohdich, F; Sanderson, MP; Seenisamy, J; Walter-Bausch, G; Zanelli, U; Hewitt, P; Esdar, C; Schadt, O Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (?5i). J Med Chem64:10230-10245 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM388323 |
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| n/a |
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| Name | BDBM388323 |
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| Synonyms: | US10294246, Compound No. 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16BN3O4 |
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| Mol. Mass. | 325.127 |
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| SMILES | OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ncccn1 |r| |
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| Structure | 
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